Effect of a 20-week multicomponent and structured exercise intervention on cognitive function in patients with mild cognitive impairment

Ajou University0 个研究点目标入组 52 人开始时间: 待定最近更新: 2020年1月14日

适应症

试验速览

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•1. One or more of the following dementia risk factors:
•1) Hypertension on medication
•2) Diabetes mellitus on oral hypoglycemic agent or insulin
•3) Dyslipidemia on medication
•4) Obesity: BMI 25kg/m2 and above
•5) Smoking: patients who have smoked at least 100 cigarettes in their lifetime and smoked more than 1 cigarette in the last month
•6) Excessive drinking: more than 170 grams of alcohol per week
•7) An educational background of less than 9 years
•8) Aerobic exercise with moderate strength (3~6 METS) less than 150 minutes per week (more than 30 minutes, more than 5 days a weak) or high-intensity aerobic exercise (>6METS) less than 60 minutes per week (20 minutes or more, 3 days or more per week)
•9) Insufficient strength exercise; do not perform 8 to 10 muscle group exercises for 10 to 15 repetitions per every exercise session for 2 days or more per week
•2. No significant daily life dysfunction: KIADL 0.42 or below
•3. The participant should not be dementia in the judgement of clinicians.
•4. Literacy
•5. Written consent to participate in the research

•1. Mental illness such as major depression disorder
•2. Dementia
•3. Other neurodegenerative diseases such as Parkinson's disease
•4. MMSE z-score -1.5 or less
•5. Malignant tumors within 5 years of not being cured
•6. Revascularization or stent insertion within 1 year
•7. Severe or unstable symptomatic cardiovascular disease
•8. Any other evidence of serious or unstable physical condition (acute or severe asthma, active gastrointestinal ulcer, severe liver disease or kidney disease enough to receive dialysis), patients with other medical conditions that may interfere with the completion of the clinical trial
•9. Severe vision loss, severe hearing loss, or communication impairment beyond which intervention and validation cannot be performed
•10. Illiteracy
•11. In case it is deemed difficult to participate in the research in cooperation with the researchers' judgment to the end
•12. In case of difficulty in safely participating in arbitration programs in the judgment of the researchers
•13. Participation in other intervention studies

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