Effects of exercise on strength of Colorectal Cancer patients undergoing Chemotherapy
Not Applicable
- Conditions
- Malignant neoplasm of colon, unspecifiedC180
- Registration Number
- RBR-7hh489b
- Lead Sponsor
- niversidade de São Paulo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Men and women over the age of 18; diagnosed with colorectal cancer; undergoing chemotherapy treatment; with access to a tablet, smartphone, laptop, or computer with an integrated video camera; and willing to appear on camera during exercise sessions to enable safety monitoring
Exclusion Criteria
Diagnosis of cardiovascular disease and neurodegenerative diseases; presenting any other health problem that interferes with the execution of the proposed exercises and evaluations; history of neuromuscular injury in the upper and lower limbs in the last 12 months; not being considered able to participate in the study after medical evaluation; refusing to sign the informed consent form
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method After intervention, we expect a significative increase in the maximum isometric torque (Nm) of knee and elbow extension and flexion, measured by an isokinetic dynamometer equipment (Biodex, System 4 Pro, New York, NY, USA) with an acquisition frequency of 100 Hz.
- Secondary Outcome Measures
Name Time Method It is expected that muscle thickness (mm) measured by ultrasound (Saevo, Ultrasound FP 102, Ribeirão Preto, SP, Brazil) will be maintained or possibly significantly increased in the flexor and extensor muscles of the knee and elbow after the intervention.;Electromyographic activity measured by wireless sensors (Trigno Lab Wireless, Delsys Inc., Boston, Massachusetts, USA) is expected to increase significantly after the intervention in the knee and elbow flexor and extensor muscles.;The intervention is expected to alter the expression of microRNAs that will be analyzed by the real-time PCR method.;Quality of life, as assessed by applying the Functional Assessment of Cancer Therapy Colorectal (FACT-C, version 4) questionnaire, is expected to improve after intervention.;Cancer-related fatigue, as assessed by the Fatigue Assessment Scale (FAS), is expected to reduce after the intervention.