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临床试验/NCT06671028
NCT06671028尚未招募不适用

Ropivacaine Versus Ropivacaine with Lidocaine Mixture in Poplitial-Sciatic Nerve Block for Below Knee Surgeries- a Randomized, Single Center Study

Lawson Health Research Institute0 个研究点目标入组 110 人开始时间: 2025年1月1日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
尚未招募
入组人数
110
主要终点
Time to complete sensory block

研究概览

简要总结

Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult patients (≥18 years old)
  • Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc
  • Capable of providing informed consent

排除标准

  • History of allergic reaction to local anesthetics
  • Pre-existing neurological disorders affecting lower limbs
  • Significant renal or hepatic impairment
  • Pregnancy or breastfeeding
  • Less than 60kg
  • Inability to provide informed consent

研究组 & 干预措施

Ropivacaine

Active Comparator

Popliteal block using Ropivacaine 100 mg in 20 mL

干预措施: Ropivacaine 0,5% (Drug)

Ropivacaine anmd Lidocaine

Experimental

Popliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL

干预措施: Ropivacaine and Lidocaine (Drug)

结局指标

主要结局

Time to complete sensory block

时间窗: Tested every 2 min up to 60 min

The primary outcome is onset time for achievement of complete sensory block of the sciatic nerve determined via pinch test.

次要结局

  • Duration of analgesia(up to 48 hours after discharge)
  • Pain score at 6 hour post-block(6 hours after nerve block)
  • Patient satisfaction(at 48 hour)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Cheng Lin

Anesthesiologist

Lawson Health Research Institute

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