Mixed Local for Sciatic Block

Not Applicable

Not yet recruiting

• Conditions: Regional Anesthesia; Local Anesthetic
• Interventions: Drug: Ropivacaine 0,5%; Drug: Ropivacaine and Lidocaine

• Registration Number: NCT06671028
• Lead Sponsor: Lawson Health Research Institute

Brief Summary

Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-10
• Study First Submitted: 2024-10-31
• Study First Submitted QC: 2024-10-31
• Last Update Submitted: 2024-10-31
• Study First Posted: 2024-11-04
• Last Update Posted: 2024-11-04
• Study Start: 2025-01-01
• Primary Completion: 2027-01-01
• Study Completion: 2027-07-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• Adult patients (≥18 years old)
• Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc
• Capable of providing informed consent

Exclusion Criteria

• History of allergic reaction to local anesthetics
• Pre-existing neurological disorders affecting lower limbs
• Significant renal or hepatic impairment
• Pregnancy or breastfeeding
• Less than 60kg
• Inability to provide informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ropivacaine	Ropivacaine 0,5%	Popliteal block using Ropivacaine 100 mg in 20 mL
Ropivacaine anmd Lidocaine	Ropivacaine and Lidocaine	Popliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL

Primary Outcome Measures

Name	Time	Method
Time to complete sensory block	Tested every 2 min up to 60 min	The primary outcome is onset time for achievement of complete sensory block of the sciatic nerve determined via pinch test.

Secondary Outcome Measures

Name	Time	Method
Duration of analgesia	up to 48 hours after discharge	Patient self reported time to onset of pain or analgesics
Pain score at 6 hour post-block	6 hours after nerve block	Numeric rating scale of patient self-reported pain at 6 hour after block placement
Patient satisfaction	at 48 hour	5 point categorical