Effect of drop AMEED on corneal repair after trans-PRK
Phase 3
Completed
- Conditions
- Refractive error (Corneal disorders after trans-epithelial photorefractive keratectomy)Amnion, Photorefractive keratectomy, Wound healing, Refractive surgical procedures
- Registration Number
- TCTR20230306001
- Lead Sponsor
- anobiotechnology Research Center of Baqiyatallah university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
1. Age 20-50 years old
2. Patients with refractive problems whose Range of spherical equivalent is between -5 to -1.5
Exclusion Criteria
1. History of using topical ophthalmic drugs in the past three months
2. Any history of eye surgery
3. Use of drugs that affect the tear profile (such as: blood pressure medication, rheumatism medication, anti-psychotic medication, etc.)
4. History of any eye diseases other than refractive disorders
5. Patients with diabetes history
6. Patients with drug allergy
7. History of any systemic diseases especially rheumatologic disease
8. Patients with anisometric eyes
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method size of corneal epithelial defects daily in both groups until the complete epithelial healing The patients' eyes are stained with fluorescein, and a photo of the stained part is taken with a photo slit device. The size of the defect in the picture will be determined by ImageJ software.
- Secondary Outcome Measures
Name Time Method the corneal haziness 1st, 3rd, 6th months after surgery in both group measured the corneal haziness according to the standard evaluation ,pain measurement First, second and third day after surgery in both group The pain measurement was based on a 0-10 Likert scale.,conjunctival injection grading First, second and third day after surgery in both group using the Efron system,visual acuity 1st, 3rd, 6th months after surgery in both group using the Snellen chart