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Clinical Trials/NCT04754503
NCT04754503
Recruiting
Not Applicable

Survival and Quality of Life After Liver Transplantation in Patients Aged 65 and Over

Gérond'if1 site in 1 country125 target enrollmentApril 9, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Patients Suitable for a Liver Transplant
Sponsor
Gérond'if
Enrollment
125
Locations
1
Primary Endpoint
Assessment of survival and quality of life after liver transplantation according to the quality of life score
Status
Recruiting
Last Updated
3 years ago

Overview

Brief Summary

The main objective of this non-interventional, single-center study is to assess survival and associated factors at 1 year in patients aged 65 and over who received liver transplantation

Detailed Description

The expected benefits of this study are to identify the preoperative risk factors of mortality from liver transplant failure in patients aged 65 and over (90-day mortality and 1 and 3-year survival) will allow better selection. candidates for this age group. In the current context of organ shortage, this study should make it possible to reduce the number of risky transplants and thus improve the allocation of grafts.Inclusion of patients who meet the inclusion criteria will be carried out during their hospitalization in the surgical department of the hepato-bilary center. Included patients will receive a standardized geriatric assessment in addition to the usual assessment for a liver transplant. The geriatric assessment will be carried out and conducted as follows: geriatric scores and quality of life questionnaires. Two geriatricians will perform the physical examination and blindly estimate each other's probability of survival at 90 days using a Likert scale. Geriatricians will be blinded to hepatic data (reasons for transplantation). The consultation as well as the completion of the questionnaire will be carried out during the pre-transplantation assessment. Survival and quality of life will be assessed at 3 and 12 months post-transplantaion.

Registry
clinicaltrials.gov
Start Date
April 9, 2021
End Date
April 2025
Last Updated
3 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Gérond'if
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Candidates for liver transplantation
  • Having expressed non-oppostion to his participation in study and documented in his medical file
  • With social coverage

Exclusion Criteria

  • Emergency transplant patients
  • Patient already included in another study
  • Patient under guardianship or curatorship
  • Expressing his opposition to participate in the study

Outcomes

Primary Outcomes

Assessment of survival and quality of life after liver transplantation according to the quality of life score

Time Frame: 12 Months

Secondary Outcomes

  • Detecting depression in the elderly according the Geriatric Depression Scale (GDS)(12 Months)

Study Sites (1)

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