Survival and Quality of Life After Liver Transplantation in Patients Aged 65 and Over

Recruiting

• Conditions: Patients Suitable for a Liver Transplant

• Registration Number: NCT04754503
• Lead Sponsor: Gérond'if

Brief Summary

The main objective of this non-interventional, single-center study is to assess survival and associated factors at 1 year in patients aged 65 and over who received liver transplantation

Detailed Description

The expected benefits of this study are to identify the preoperative risk factors of mortality from liver transplant failure in patients aged 65 and over (90-day mortality and 1 and 3-year survival) will allow better selection. candidates for this age group. In the current context of organ shortage, this study should make it possible to reduce the number of risky transplants and thus improve the allocation of grafts.Inclusion of patients who meet the inclusion criteria will be carried out during their hospitalization in the surgical department of the hepato-bilary center.

Included patients will receive a standardized geriatric assessment in addition to the usual assessment for a liver transplant.

The geriatric assessment will be carried out and conducted as follows: geriatric scores and quality of life questionnaires. Two geriatricians will perform the physical examination and blindly estimate each other's probability of survival at 90 days using a Likert scale.

Geriatricians will be blinded to hepatic data (reasons for transplantation). The consultation as well as the completion of the questionnaire will be carried out during the pre-transplantation assessment.

Survival and quality of life will be assessed at 3 and 12 months post-transplantaion.

Study Timeline

• Study First Submitted: 2021-02-12
• Study First Submitted QC: 2021-02-12
• Study First Posted: 2021-02-15
• Study Start: 2021-04-09
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-11
• Last Update Posted: 2023-01-12
• Primary Completion: 2024-04
• Study Completion: 2025-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 125

Inclusion Criteria

• Candidates for liver transplantation
• Having expressed non-oppostion to his participation in study and documented in his medical file
• With social coverage

Exclusion Criteria

• Emergency transplant patients
• Patient already included in another study
• Patient under guardianship or curatorship
• Expressing his opposition to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of survival and quality of life after liver transplantation according to the quality of life score	12 Months

Secondary Outcome Measures

Name	Time	Method
Detecting depression in the elderly according the Geriatric Depression Scale (GDS)	12 Months

Trial Locations

Locations (1)

Geriatric Department, Paul Brousse Hospital; 🇫🇷 Villejuif, Île-de-France, France