Imatinib therapy for agressive colon cancers.

• Conditions: colon cancer; Therapeutic area: Diseases [C] - Cancer [C04]

• Registration Number: EUCTR2014-003965-11-NL
• Lead Sponsor: niversity Medical Center Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-09-15
• Last Update Posted: 7 December 2015

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Histologically proven adenocarcinoma of the colon;
2. Confirmed eligibility for surgery with curative intent as deemed by the hospital’s multidisciplinary team (MDT) review;
3. High intratumoural gene expression of PDGFR-a, PDGFR-ß, PDGF-C and KIT according to our diagnostic RT-qPCR test.

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 27
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 27

Exclusion Criteria

The presence of synchronous distant metastases;
Current hospital standard of care dictates that patient should undergo any neoadjuvant therapy;
Concurrent participation in another clinical trial using any medicinal product, or participation in such a trial in the period of three months prior to the current trial;

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified