Brain Assessment and Investigation in Heart Failure Trial - B-HeFT

Department of Cardiovascular Medicine0 sites80 target enrollmentJuly 31, 2012

Overview

Reduction in hippocampus blood flow is associated with depressive symptoms and cognitive impairment in chronic heart failure patients.

Registry

who.int

Start Date

July 31, 2012

End Date

December 31, 2013

Last Updated

2 years ago

Study Type

Observational

Sex

All

Sponsor

•(1\) Contraindication of MRI: Cardiac devices or claustrophobia. (2\) Unstable cardiac function: Patients who had uncontrolled heart failure or required intravenous inotropes. Patients receiving stent implantation for acute myocardial infarction within 3 months. (3\) Past history significantly affecting cerebral blood flow and/or brain structure: MMSE \< 24, mental retardation, neurodegenerative disease, psychiatric disorder, epilepsy, symptomatic stroke, symptomatic carotid stenosis with or without stenting or endarterectomy, head trauma, hydrocephalus, intracranial mass, alcohol/drug addiction, hypo/hyperthyroidism, aortic stenosis proximal to left cervical artery and/or severe aortic valve stenosis. (4\) Difficulty in evaluating brain and/or cardiac MRI: Artifacts of movements or other causes. Patients with complex congenital heart diseases.