Short-term Effects of Humidification Devices on Respiratory Pattern and Work of Breathing During Invasive Ventilation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Fondazione Salvatore Maugeri
- Enrollment
- 15
- Locations
- 2
- Primary Endpoint
- Change in muscle pressure-time product (PTPoes)
Study Overview
Brief Summary
This study compares the short-term effects of a new humidification system (Hygrovent Gold) and two other humidification devices (heated and moisture exchanger and heated humidifier) on respiratory pattern and work of breathing, during invasive ventilation.
Detailed Description
Three humidifying devices are commonly and indifferently used during mechanical ventilation, but their impact on respiratory mechanics and, eventually, mechanical ventilation efficacy, particularly in patients highly dependent from mechanical ventilation, are not superimposable.
It has already been described that heated and moisture exchangers (HME), increasing dead space, can negatively affect ventilatory function and gas exchange, in comparison to heated humidifiers (HH).
The Hygrovent Gold, mainly because of its position between the tracheostomy and the Y-piece of the ventilatory circuit and its structure, may lead to analogous or even worse effects, determining and increase in inspiratory resistances and dead space and consequently an increase in the work of breathing.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Chronic hypercapnic respiratory failure (PaCO2 of 45 mmHg or more)
- •Long-term mechanical ventilation via tracheostomy
- •Clinical stability
Exclusion Criteria
- •Non collaborative subjects
- •Acute respiratory failure
- •Haemodynamic instability
- •Encephalopathy
Outcomes
Primary Outcomes
Change in muscle pressure-time product (PTPoes)
Time Frame: Baseline and 60 minutes
Secondary Outcomes
No secondary outcomes reported
Investigators
Annia Schreiber
MD
Fondazione Salvatore Maugeri
