Comparison of Nebulised Dexmedetomidine, Magnesium sulphate And Dexamethasone in Prevention of Postoperative Sore throat After Tracheal Intubation in Adults: A Double-blind Randomized Control Study

Post-operative sore throat (POST) is one of the undesirable outcomes that occurs in patients following General anesthesia with endotracheal intubation. The incidence of POST varies from 14% to 50% following endotracheal intubation**.** Several risk factors have been identified for developing POST following endotracheal intubation including obesity, female sex, size of endotracheal tube, prolong duration of surgery, multiple intubation attempts, emergency intubation in intensive care unit (ICU). The intubation technique results in pathological changes including epithelial loss, glottic oedema, submucosal tears, and contact ulcer granuloma, which play an important role in POST development . Although it is self-limiting, it needs to be prevented because it seriously affects patient satisfaction and postoperative recovery. Despite the emergence of clinical trials on POST nebulization therapy, still no current overview of all the relevant drugs.Even there is lack of direct comparisons of these frequently used aerosolized drugs and lack of a clinically useful ranking of all atomizing drugs concerning both efficacy and acceptability. So in this study comparison between Nebulized Dexmedetomidine, Nebulized Magnesium sulphate and Nebulized Dexamethasone may be equally effective in the prevention of POST.