A Randomized Trial on Platelet Rich Plasma Versus Saline Dressing of Diabetic Foot Ulcers

Not Applicable

Completed

Brief Summary: New treatments for persistent DFU have emerged, among which are the bioengineered skin substitutes, extracellular matrix proteins products, matrix metalloproteinases modulators, and growth factor therapy. Platelet rich plasma (PRP) gel has been used for stimulating wound healing since the last decade of the 20th century. This randomized trial was conducted to assess the role of PRP in gel form as a treatment for clean non-healing diabetic foot ulcer in comparison to regular dressing with saline as a control.

Recruitment & Eligibility

Inclusion Criteria

adult patients of both sexes aging below 70 years with non-infected chronic foot ulcer confined to one anatomical site. Chronicity was defined as non-healing ulcer for twelve or more weeks

Exclusion Criteria

Patients with chronic limb ischemia.
Evidence of osteomyelitis in the affected foot
Exposed tendons, ligaments or bones at the base of ulcer
Patients who received radiotherapy or chemotherapy at time of study or within 3 months of its beginning.
Patients having low peripheral platelet count, low serum albumin level or low hemoglobin level

Arm && Interventions

Group	Intervention	Description
PRP gel	PRP gel	PRP gel was applied to the ulcer twice per week after preparation and then the ulcer was covered with Vaseline gauze, few layers of sterile gauze and crepe bandage.
Saline dressing	Saline dressing	daily dressing of the ulcer with normal saline was done

Primary Outcome Measures

Name	Time	Method
Percent reduction in the ulcer size	20 weeks	the difference between ulcer size before and after treatment subdivided by the ulcer size before treatment

Secondary Outcome Measures

Name	Time	Method

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