Preoperative Administration of Heparin as Thromboprophylaxis in Major Thoracic Surgery
- Registration Number
- NCT02940444
- Lead Sponsor
- West China Hospital
- Brief Summary
Thromboembolism is an important perioperative complication in major thoracic surgery, even though current guidelines have recommended postoperative administration of heparin or LMWH for thromboprophylaxis for those high-risk patients, there are still many cases of thromboembolism. Therefore, as the guideline itself writes, the investigators believe the rational of dose and timing of heparin in thoracic surgery are still not well established. Therefore, the investigators aimed to conduct this randomized controlled study to explore the safety and efficacy of preoperative Administration of Heparin as Thromboprophylaxis in Major Thoracic Surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 2000
- 18-75 years old without any preoperative VTEs;
- patients undergoing major thoracic surgery (including lobectomy, esophagectomy, and thymectomy).
- patients with coagulation disorders: preoperative international normalized ratio (INR) > 1.5, or blood platelet count < 50x10^9/L;
- patients receiving any therapeutic anticoagulation preoperatively;
- patients with severe renal or liver dysfunction.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description control group Heparin start heparin sodium (5000 IU,BID) from postoperative day 1, and continue until discharge case group Heparin start heparin sodium (5000IU, BID) upon admission, and continue until discharge
- Primary Outcome Measures
Name Time Method INR on postoperative day 1 for both group blood platlet count(/L) on postoperative day 1 for both group chest tube drainage volume (ml) from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy ) APTT (s) on postoperative day 1 for both group intraoperative bleeding volume (ml) the bleeding volume (ml) during operation in the operation room for all patients During the operation, the blood loss of each patient was collected and measured, and recorded by the investigators.
PT(s) on postoperative day 1 for both group thromboembolism occurence rate (%) within 30 days after surgery chest tube drainage duration (days) from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy )
- Secondary Outcome Measures
Name Time Method APTT(s) rightly upon hospital admission day PT(s) rightly upon hospital admission day INR rightly upon hospital admission day blood platlet count(/L) rightly upon hospital admission day
Trial Locations
- Locations (1)
Department of thoracic surgery, west china hospital, sichuan university
🇨🇳Chengdu, Sichuan, China