ano-MRI on 7 Tesla: A technical validation study in rectal and breast cancer - Nano MRI on 7T in rectal and breast cancer

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年4月23日

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•General criteria:
•- Age > 18 years;Inclusion criteria rectal cancer patients:
•- Patients with recently histologically proven rectal cancer, who are either:
•o Planned to undergo a total mesorectal excision without neo-adjuvant radiotherapy.
•o Planned to undergo a short radiotherapy program (5x5 Gy) followed by a total mesorectal excision in the next week.;Inclusion criteria breast cancer patients:
•- Patients with recently diagnosed breast cancer who: ;o Have proven axillary lymph node involvement based on cytological analysis of ultrasound guided fine needle aspiration of suspicious axillary lymph nodes and receive no neoadjuvant therapy.
•o have an estimated invasive primary tumor size of 2-5 cm (cT2) and are planned for surgery with sentinel node procedure, but will receive no neo-adjuvant therapy and are not of low grade based on histopathological analysis of the core needle biopsy specimen.
•o will undergo an axillary lymph node dissection without prior sentinel node procedure and will receive no neo-adjuvant therapy.

•- Abdominal circumference > 120 cm
•- Pregnancy
•- Karnofsky score <= 70
•- Contraindications for 7T MRI
•- Contraindications for ferumoxtran;Specific for patients with rectum carcinoma:
•- Inflammatory bowel disease
•- Prior oncological related abdominal and/or pelvic surgery or radiotherapy;Specific for patients with breast carcinoma:
•- Prior radiotherapy or surgery to axillae

发起方

niversitair Medisch Centrum Sint Radboud