The Role of Natural Orifice Specimen Extraction Surgery (NOSES) in Treating Right-sided Colon Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 349
- 试验地点
- 1
- 主要终点
- The rate of postoperative complications
研究概览
简要总结
The purpose of this study is to investigate the short-term and long-term outcomes between natural orifice specimen extraction surgery (NOSES) and totally laparoscopic right hemicolectomy (TLRH). The hypothesis is that NOSES could achieve good short-term and oncological outcomes for right colon cancer patients.
详细描述
This study is a retrospective clinical study. We reviewed collected data from all patients who underwent laparoscopic curative resection for stage I-III right-sided colon cancer between January 2018 and January 2023. A total of consecutive 115 patients who underwent laparoscopic resection with transvaginal or transrectal specimen extraction were identified as the NOSES group. To establish a comparative cohort, 234 patients who underwent totally laparoscopic right hemicolectomy (TLRH) during the same period were selected. The purpose of this study is to investigate the short-term and long-term outcomes between NOSES and TLRH. The hypothesis is that NOSES could promote postoperative recovery, reduce incision-related complications with comaprable long-term oncological outcomes when compared with TLRH.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Biopsy proven colon carcinoma;
- •Imaging diagnosis of T1-3 colon cancer;
- •The tumor located in the cecum, ascending colon, or colonic hepatic flexure;
- •Written informed consent;
排除标准
- •Complete intestinal obstruction;
- •Hepatitis activity and peripheral neuropathy (such as peripheral neuritis, pseudo meningitis, motor neuritis, and sensory impairment);
- •Significant organ dysfunction or other significant diseases, including clinically relevant coronary artery disease, cardiovascular disease, or myocardial infarction within the 12 months before enrollment; severe neurological or psychiatric history; severe infection; active disseminated intravascular coagulation;
- •Pregnancy or breastfeeding;
- •Alcohol abuse or drug addiction;
- •Concurrent uncontrolled medical condition;
结局指标
主要结局
The rate of postoperative complications
时间窗: up to 30 days
The rate of postoperative complications = patients with any postoperative complications/all cases.
次要结局
- Operating time(up to 1 days)
- The time of first flatus(up to 5 days)
- Postoperative hospitalization(up to 30 days)
研究者
Haitao Zhou
Professor Haitao Zhou
National Cancer Center, China