Study on the Correlation Between Neurotrophic Factors and the Condition of Stroke Patients

Not Applicable

Recruiting

• Conditions: Stroke
• Interventions: Other: Conventional treatment; Behavioral: computerized cognitive training system; Procedure: acupuncture; Behavioral: aerobic exercise; Behavioral: tranditional cognitive training

• Registration Number: NCT05479903
• Lead Sponsor: Chongqing Medical University

Brief Summary

Stroke is currently the most common disabling disease, which often leads to impairment of sensory, motor, speech and psychological functions, resulting in a reduced quality of life for patients. Therefore, post-stroke functional rehabilitation, especially the rehabilitation of physical function and psychological condition, is particularly important for patients to rejoin society. Acupuncture can promote the functional recovery of patients and facilitate the rehabilitation of limb function, thus improving the quality of survival of post-stroke patients.

Neurotrophic factors are diverse, most of which are mainly derived from neuronal cells in the central nervous system and are involved in a variety of neurological functions such as cell growth, differentiation and plasticity, thus promoting recovery of multiple functions after stroke. Many studies have found that different interventions affect the prognosis of stroke patients differently, e.g., long-term acupuncture increases serum levels of brain-derived neurotrophic factor in stroke patients and also has better outcomes than controls in post-stroke neurological recovery and the development of post-stroke psychiatric disorders.

This study investigated the effects of different therapeutic measures on patients' functional recovery and neurotrophic factors by setting up a controlled and blinded trial design, which could not only provide clinical evidence for the effectiveness of relevant therapeutic measures, but also verify the clinical value of certain neurotrophic factors (e.g., predicting outcome, assessing condition, and preventing adverse events).

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-16
• Status Verified: 2022-07
• Study First Submitted: 2022-07-21
• Study First Submitted QC: 2022-07-27
• Last Update Submitted: 2022-07-27
• Study First Posted: 2022-07-29
• Last Update Posted: 2022-07-29
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Symptom recognition to admission ≤ 72 hours
• Clear imaging evidence
• Diagnosis of spontaneous cerebral hemorrhage by an immobilized physician according to relevant guidelines; pre-onset mRS score ≤ 1

Exclusion Criteria

• This onset was caused by traumatic and violent factors
• History of previous intracranial surgery
• Previous cerebrovascular accident
• Previous speech disorders and limb movement disorders
• Participation in other trials in the last three months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sham acupuncture stroke group	Conventional treatment	-
computerized cognitive training group	computerized cognitive training system	-
acupuncture stroke group	acupuncture	-
no acupuncture stroke group	Conventional treatment	-
tranditional cognitive training group	aerobic exercise	-
tranditional cognitive training group	Conventional treatment	-
aerobics group	Conventional treatment	-
acupuncture stroke group	Conventional treatment	-
acupuncture healthy group	acupuncture	-
computerized cognitive training group	Conventional treatment	-
aerobics group	tranditional cognitive training	-

Primary Outcome Measures

Name	Time	Method
modified rankin scale	Change of the score of modified rankin scale from Baseline at 3 months after onset of disease	The mrs (modified rankin scale) is a scale used to assess the patient's ability to care for himself/herself, which is composed of independent walking ability, self-perceived symptoms, and ability to control bowel and urine.Assessment results range from 0-6 points，a higher score means a worse ending

Secondary Outcome Measures

Name	Time	Method
Mini-mental State Examination	Change of the score of modified rankin scale from Baseline at 1 week, 2 weeks, 1 month, 2 months, 3 months after onset of disease	The MMSE (Mini-mental State Examination) is a scale that assesses patients' cognition in terms of calculation, orientation, memory, and recall on a scale of 0-30, which is combined with the patient's level of education to yield results for different levels of cognitive impairment.

Trial Locations

Locations (1)

Yongchuan Hospital of Chongqing Medical University; 🇨🇳 Chongqing, China