Determining Normal Range for Free Light Chains in Serum Among Twins
- Conditions
- Multiple Myeloma
- Interventions
- Device: Free light chains
- Registration Number
- NCT04191057
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
The objective of this study is to recruit healthy adult identical and fraternal twins for the collection of one teaspoon of blood to be sent to the Clinical Lab at San Francisco General Hospital. The serum will be tested to determine the reference range for free light chains.
- Detailed Description
Serum free light chains are used to assist in the diagnosis of multiple myeloma. The test measures kappa (K) and lambda (L) chains, and the calculation of the ratio of kappa to lambda (K/L). Previous studies have shown that the K/L ratio does not change over time (1 year). The hypothesis of this study is that healthy twins will have a K/L ratio that are close to each other in value, suggesting that this ratio is genetically linked.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 32
- Healthy subjects 18-80 years.
- Must be an identical or fraternal twin (both must be recruited)
- Symptoms suggestive of multiple myeloma (e.g., renal insufficiency, anemia, bone pain) -
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Healthy twin Free light chains Free light chains of twins compared to non-twin siblings
- Primary Outcome Measures
Name Time Method Free light chain reference range One month after the completion of the enrollment Determination of the normal range for free light chains
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
San Francisco General Hospital
🇺🇸San Francisco, California, United States