COMPARING THE DIAGNOSTIC AND PROGNOSTIC ACCURACY OF PROKINETICIN-2 AND PROCALCITONIN FOR SEPSIS IN CRITICALLY ILL PATIENTS: A PROSPECTIVE OBSERVATIONAL STUDY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To evaluate and compare diagnostic and prognostic value of Prokineticin-2 and Procalcitonin in critically ill sepsis patients
研究概览
简要总结
Sepsis is a syndrome of physiologic, pathologic, and biochemical abnormalities induced by infection. Early diagnosis and appropriate treatment are key to reduce mortality due to sepsis. Biomarkers play an important role in early diagnosis and prognostication of patients in sepsis.
Patients having clinical features suggestive of sepsis as defined by Sepsis-3 definition (2016) at the time of ICU admission will be enrolled in the study. As a part of routine blood sampling in ICU, whole blood will be taken for the purpose of serum Procalcitonin and Prokineticin-2 estimation on Day 1, Day 7 or on day of discharge or death ( whichever is earlier )and on Day 28. Values of biomarkers will be assessed by ELISA kit method. Diagnostic and Prognostic value of biomarkers will be compared from the values obtained.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients having clinical features suggestive of sepsis as defined by Sepsis-3 definition (2016) at the time of ICU admission.
排除标准
- •Patients/ relatives who refused to give informed consent.
- •Age less than 18 years.
- •Patients with terminal stage of disease (malignancy , Acquired immunodeficiency Syndrome, end stage liver or renal disease).
- •HIV/HBSAG/HCV .
- •Autoimmune disorders/ metabolic diseases.
- •On long term steroids/ immunosuppressants/ chemotherapy Osteoarthritis.
结局指标
主要结局
To evaluate and compare diagnostic and prognostic value of Prokineticin-2 and Procalcitonin in critically ill sepsis patients
时间窗: Day 1, Day 7 or on day of discharge or death (whichever is earlier) and on day 28
次要结局
- 1) Ability of Prokineticin-2 to prognosticate the multi-organ failure in critically ill patients as assessed by SOFA scores.(2) To establish Prokineticin-2 as a predictor of outcome of sepsis in terms of 28 days mortality)