Comparing two biochemical markers prokineticin-2 and procalcitonin for predicting the outcome of infection in patients admitted in ICU

Not yet recruiting

Conditions: Other specified bacterial agents as the cause of diseases classified elsewhere,

Brief Summary: Sepsis is a syndrome of physiologic, pathologic, and biochemical abnormalities induced by infection. Early diagnosis and appropriate treatment are key to reduce mortality due to sepsis. Biomarkers play an important role in early diagnosis and prognostication of patients in sepsis.

Patients having clinical features suggestive of sepsis as defined by Sepsis-3 definition (2016) at the time of ICU admission will be enrolled in the study. As a part of routine blood sampling in ICU, whole blood will be taken for the purpose of serum Procalcitonin and Prokineticin-2 estimation on Day 1, Day 7 or on day of discharge or death ( whichever is earlier )and on Day 28. Values of biomarkers will be assessed by ELISA kit method. Diagnostic and Prognostic value of biomarkers will be compared from the values obtained.

Recruitment & Eligibility

Inclusion Criteria

Patients having clinical features suggestive of sepsis as defined by Sepsis-3 definition (2016) at the time of ICU admission.

Exclusion Criteria

Patients/ relatives who refused to give informed consent.
Age less than 18 years.
Patients with terminal stage of disease (malignancy , Acquired immunodeficiency Syndrome, end stage liver or renal disease).
HIV/HBSAG/HCV .
Autoimmune disorders/ metabolic diseases.
On long term steroids/ immunosuppressants/ chemotherapy Osteoarthritis.

Primary Outcome Measures

Name	Time	Method
To evaluate and compare diagnostic and prognostic value of Prokineticin-2 and Procalcitonin in critically ill sepsis patients	Day 1, Day 7 or on day of discharge or death (whichever is earlier) and on day 28

Secondary Outcome Measures

Name	Time	Method
1) Ability of Prokineticin-2 to prognosticate the multi-organ failure in critically ill patients as assessed by SOFA scores.	2) To establish Prokineticin-2 as a predictor of outcome of sepsis in terms of 28 days mortality

Locations (1): All India Institute of Medical Sciences, Jodhpur
🇮🇳
Jodhpur, RAJASTHAN, India
All India Institute of Medical Sciences, Jodhpur
🇮🇳Jodhpur, RAJASTHAN, India
Kavyashree Bhat
Principal investigator
9480853067
kavyashreebhat7@gmail.com