Clinical efficacy analysis of drug use tigecycline for re-creation of antimicrobial agents for treatment of Scrub typhus.

Inha University Hospital0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年3月4日

适应症

试验速览

暂无简介。

•1. Among inpatients 19 years of age or older who have a fever of 37.5°C or higher (tympanic temperature measurement standard), rash, or crusts suspected of tsutsugamushi, who voluntarily decided to participate in the study
•2. Patient is diagnosed with tsutsugamushi disease by department of infectious disease specialist
•3. After hearing and fully understanding the detailed explanation of this clinical study, a person who voluntarily decides to participate and agrees in writing to abide by the precautions

•1. Exclusion complications: Patients with severe complications such as respiratory distress pneumonia, encephalitis (Investigator decides on final exclusion)
•2. Chronic renal dysfunction patient
•3. Patient with a body weight of <45kg
•4. Immunocompromised patients: Administration of glucocorticoid and/or immunoglobulins for long-term
•5. Pregnant woman
•6. For both male and female patients, the patient and his or her partner of childbearing
•potential who does not agree to use a highly effective or medically acceptable methods of
•contraception during the course of the study and for 3 months following discontinuation of study drug as specified below:
•* IUD (Intrauterinedevice), Barrier contraception that must include spermicide (for women's contraceptive diaphragm/vaginal sponge sponge/cervical cap) and double-blocking method (excluding simultaneous use of male and female condoms) with male condom use, infertility Procedures (vasectomy, vasectomy, tubal ligation, etc.)
•7. Unable to take medications by mouth
•8. Received any anti-rickettsia drug (including rifampin, chloramphenicol, macrolide, quinolone and tetracycline)
•9. Patients with shock or multiple organ failure that require vasopressors/vasoconstrictors, patients with reduced consciousness, patients with respiratory failure that require mechanical ventilation, patients with renal failure requiring hemodialysis
•10. Diagnosed with a disease other than tsutsugamushi

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