Computerised Assessment of Visual Neglect Symptoms in Peripersonal Space
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Test performance of young study participants in the encircling monitor system with/without cathodal stimulation
研究概览
简要总结
Healthy subjects will undergo cathodal stimulation of the right posterior parietal Cortex (PPC) and assessment of neglect-like symptoms in the encircling monitor system (EMS) as well as in a standard clinical test (Test Battery for Attention Performance, TAP, Zimmermann & Fimm, 1993). The aim of this study is to investigate whether cathodal stimulation leads to poorer test performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Younger subjects
- •aged between 18 and 35 years
- •ability to provide written informed consent
- •right-handedness
- •Elderly subjects
- •aged between 50 and 85 years
- •ability to provide written informed consent
- •right-handedness
排除标准
- •Exclusion criteria for both groups:
- •serious psychiatric disorders (including depression, psychosis) in the past
- •severe neurological disorders (such as epilepsy, dementia, stroke) in the past
- •current severe medical disorder
- •drugs, medication or alcohol abuse at the time of the study
- •severe traumatic brain injury or tumor in the past
- •operations on the brain, trepanations
- •metallic implants in the head / neck area (except in the mouth), such as screws, splinter, artificial cochlea, electrodes
- •severe skin diseases (like eczema) or very sensitive skin in the head region in the past
- •epilepsy in the family
- •current use of neuroleptics, antiepileptics, antidepressants, L-dopa, benzo-diazepines
- •current pregnancy or lactation
- •current claustrophobia
研究组 & 干预措施
Cathodal tDCS in young study participants
Cathodal tDCS in young study participants
干预措施: Cathodal tDCS (Other)
Cathodal tDCS in elderly study participants
Cathodal tDCS in elderly study participants
干预措施: Cathodal tDCS (Other)
Sham tDCS in young study participants
Sham tDCS in young study participants
干预措施: Sham tDCS (Other)
Sham tDCS in elderly study participants
Sham tDCS in elderly study participants
干预措施: Sham tDCS (Other)
结局指标
主要结局
Test performance of young study participants in the encircling monitor system with/without cathodal stimulation
Comparison of the young subjects' performance with vs. without transcranial direct current stimulation (tDCS) in the following computerised tests: Star Cancellation (number of omissions, latency \& crossing index; based on Rabufetti, 2012), Landmark (reaction times, accuracy; based on Giglia et al., 2011), Visual Detection (reaction times, omissions; based on Sparing et al., 2009), Extinction (number of correct responses; based on Niedeggen \& Hoffmann, 2011)
次要结局
- Test performance of study participants in the Test Battery for Attention Performance (TAP) with/without cathodal stimulation
- Test performance of elderly study participants in the encircling monitor system with/without cathodal stimulation
- Comparison of visual search patterns between neglect patients and healthy subjects with cathodal stimulation
研究者
Andreas Meisel
Prof. Dr. med. Andreas Meisel
Charite University, Berlin, Germany