Evaluation of a LAMP Assay for T. Pallidum. Pertenue
Completed
- Conditions
- Yaws
- Registration Number
- NCT04753788
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Brief Summary
This is a diagnostic evaluation comparing the performance of real-time PCR performed at a national reference laboratory and a LAMP assay performed at a regional hospital for the diagnosis of yaws
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 563
Inclusion Criteria
- Lesion consistent with yaws
- Positive treponemal and non-treponemal antibodies assessed by the DPP Syphilis Screen and Confirm RDT
Exclusion Criteria
- Unable to give consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sensitivity of LAMP vs qpCR 15 Months A case of Yaws Positive for T.pallidum DNA by PCR that is also positive by LAMP
Specificity of LAMP for Yaws 15 Months Sample negative by qPCR for T.pallidum that is also negative by LAMP
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (3)
Centre Pasteur
🇨🇲Yaoundé, Cameroon
Institut Pasteur
🇨🇮Abidjan, Côte D'Ivoire
Noguchi Memorial Institute of Medical Research
🇬🇭Accra, Ghana
Centre Pasteur🇨🇲Yaoundé, Cameroon