The Effects of Clonidine on Postoperative Analgesia After Single Shot Femoral Nerve Block Following Arthroscopic Knee Surgery in Children
Trial Snapshot
- Phase
- Phase 2
- Status
- Withdrawn
- Locations
- 1
- Primary Endpoint
- Pain
Study Overview
Brief Summary
Knee arthroscopy is a common surgical procedure in pediatrics in which the knee joint is visualized through a small camera to help diagnose and treat knee problems. This procedure is commonly accomplished with the use of general anesthesia. Regional anesthesia is commonly completed with a single injection of local anesthetic around the femoral nerve to provide pain relief for several hours following knee arthroscopy. The intent of this study is to examine the effects of clonidine in addition to local anesthetics for femoral nerve blockade in providing children and adolescents post-operative analgesia. The investigators hypothesize the addition of low dose clonidine (1 mcg/kg) provides an additional 4 hours of post operative analgesia following arthroscopic knee surgery and reduces post-operative opiate requirement.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- — to 21 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •American Society of Anesthesiologist (ASA) functional status I or II
- •Patients scheduled for arthroscopic knee surgery only
Exclusion Criteria
- •Patients with history of chronic opioid therapy, central or peripheral neuropathy, contraindications to regional anesthesia, history of allergy to clonidine or ropivicaine, or anterior cruciate ligament reconstructive surgery in addition to knee arthroscopy
Arms & Interventions
Ropivacaine plus clonidine
Ropivacaine plus clonidine for femoral block
Intervention: Clonidine (Drug)
Ropivacaine
Ropivacaine alone for femoral block
Intervention: Ropivacaine (Drug)
Outcomes
Primary Outcomes
Pain
Time Frame: 24 hours
The primary end-point of the study is time from performance of femoral nerve block to onset of pain in the distribution of the femoral nerve.
Secondary Outcomes
- Blood pressure(15, 30 & 60 mins. post-op)
- Oxygen saturation(15, 30 & 60 mins. post-op)
- Heart rate(15, 30 & 60 mins. post-op)