NCT00242671已完成3 期
The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane.
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 试验地点
- 1
- 主要终点
- Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score
研究概览
简要总结
The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Elective gynecological procedure
- •Age 18-80 years
- •Signed informed consent
排除标准
- •Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol
- •Active smoking, asthma or other history of hyper-reactive airway disease
- •History of chronic obstructive lung disease limiting exercise
- •History of angina, previous myocardial infarction, valvular heart disease, or heart surgery
- •Presence of heart murmurs or neck bruits
- •ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities,
- •History of difficult airway access
- •Pulmonary hypertension and/or right ventricle dysfunction
- •History of bulous emphysema, and/or spontaneous pneumothorax
- •History of alcohol or drugs abuse
- •Known history of psychiatric illness and/or medications
- •Patients that required postoperative mechanical ventilation for any reason
结局指标
主要结局
Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score
次要结局
- Quality of recovery in the recovery room as indicated by the level of consciousness, incidence of nausea, vomiting, shivering and other phenomena occuring during recovery
研究者
研究点 (1)
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