"Can You Treat Knee Arthritis Without Surgery? Looking at Genicular Artery Embolization"

Phase 3

Not yet recruiting

• Conditions: Unilateral primary osteoarthritisof knee,

• Registration Number: CTRI/2025/06/088633
• Lead Sponsor: All India institute of medical sciences Mangalagiri

Brief Summary

Osteoarthritis (OA) of the knee is a degenerative condition leading to chronic pain and reduced quality of life. Traditional treatments include non-steroidal anti-inflammatory drugs, intraarticular injections, and, ultimately, Total Knee Arthroplasty (TKA) for severe cases. However, TKA carries risks and prolonged recovery. Genicular Artery Embolization (GAE) is emerging as a minimally invasive alternative that targets neovascularization and inflammatory processes driving OA symptoms. This project evaluates the efficacy, safety, and outcomes of GAE in improving quality of life for patients with chronic knee OA who are refractory to medical therapy. Through literature review, clinical procedures, and patient follow-up, the study aims to assess symptom reduction, cost-effectiveness, and predictors of successful outcomes. The work involves a longitudinal study with a calculated sample size of 21 patients, evaluating symptom changes via WOMAC and KOOS scores over three months. Data analysis includes paired t-tests and repeated measures ANOVA to determine significance. If proven effective, GAE may offer a safer, faster-recovery alternative to surgical interventions, reshaping OA management and expanding minimally invasive options. This study is especially relevant in India, where GAE is still emerging, and could drive future research into its broader clinical application.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-06-30
• Last Update Posted: 2025-11-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Symptomatic patients aged 40 years and older diagnosed with Chronic OA knee based on clinical features and Knee radiographs.
• (Kellen- Lawrence Grade 1-3) 2.
• Failed medical management for OA knee.
• Unwilling to Undergo TKA/ Not surgically fit for TKA.

Exclusion Criteria

• Kellen – Lawrence Grade 4 on Knee radiograph 2.
• Active Knee infection 3.
• Underlying Inflammatory arthritis 4.
• Severe Peripheral Vascular disease (PVD) 5.
• Allergy to contrast media 6.
• Severe renal Impairment (eGFR less than 30 ml/min/1.73m2).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
At least 25% improvement in the WOMAC and KOOS scores , post intervention	1 month, 3 months and 6 months post procedure

Trial Locations

Locations (1)

All India Institute of Medical Sciences; 🇮🇳 Guntur, ANDHRA PRADESH, India

All India Institute of Medical Sciences

🇮🇳Guntur, ANDHRA PRADESH, India

Yugandhar Samireddypalle

Principal investigator

9930237652

yugu.samireddypalle@gmail.com