Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections

Not Applicable

Recruiting

• Conditions: Infection Post Op; Hysterectomy; Prophylactic; Antibiotics

• Registration Number: NCT05337566
• Lead Sponsor: Helsinki University Central Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-4-14
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Women undergoing hysterectomy for benign indication in University Hospitals<br> (Helsinki University Hospital, Turku University Hospital, Tampere University<br> Hospital, Oulu University Hospital and Kuopio University Hospital) who have not any<br> contraindications for azithromycin or cefuroxime.<br><br>Exclusion Criteria:<br><br> - Inability to understand the study protocol.<br><br> - Allergy for either cefuroxime or azithromycin.<br><br> - Congenital or acquired prolonged Q-T-corrected interval. All the participants will<br> be asked about arrhythmias and whether they have congenital arrhythmias in the<br> family,<br><br> - Electrocardiogram will be checked for all the participants.<br><br> - Use of medicines that may prolong Q-T-corrected interval (class Ia arrhythmia<br> medications, quinidine, procainamide, and class III arrhythmia medications<br> dofetilide, amiodarone and sotalol).<br><br> - Use of selective serotonin reuptake inhibitor medication and prolonged Q-T-corrected<br> interval.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of post-hysterectomy episodes with deep infections

Secondary Outcome Measures

Name	Time	Method
Number of other post-hysterectomy infections or fever episodes