A single-centre randomised controlled trial of Antibiotic Prophylaxis before second-trimester Genetic Amniocentesis in women: the APGA trial
Not Applicable
Completed
- Conditions
- Preterm Premature Rupture Of Membranes (pPROM), foetal deathPregnancy and ChildbirthPremature rupture of membranes
- Registration Number
- ISRCTN30372886
- Lead Sponsor
- CERMET (Certification and Research for Quality) and Total Quality Management (Italy)
- Brief Summary
2009 results in https://pubmed.ncbi.nlm.nih.gov/19294678/ (added 10/06/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 34923
Inclusion Criteria
1. Pregnant women aged greater than or equal to 18 years
2. All women requested a second trimester genetic amniocentesis with the same chosen operator
Exclusion Criteria
1. Non-viable foetus (also found after the randomisation)
2. Major foetal abnormalities (also found after the randomisation)
3. Leakage of amniotic fluid
4. Bleeding in the past week
5. Fever
6. Use of any antibiotics within the past 14 days or of long-acting injectable penicillin
7. Known allergy to the specific antibiotic used
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method