The influence of omeprazole and pantoprazole on the platelet reactivity and inhibition of platelet aggregration of clopidogrel.
Phase 4
Completed
- Conditions
- Activity of clopidogrelprophylaxis against NSAID induced gastric damage1001108210018027
- Registration Number
- NL-OMON32694
- Lead Sponsor
- Atrium Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 27
Inclusion Criteria
1. Use of clopidogrel and aspirin or carbasalate calcium.
2. Use of omeprazole as prophylaxis against NSAID induced gastric damage.
3. Written informed consent.
4. 18 years or older.
Exclusion Criteria
1. Use of medication which affects the metabolism of clopidogrel
2. Severe adverse reaction or hypersensitivity reaction to pantoprazole.
3. Gastrointesnital ulcer.
5. Renal impairment (creatinine> 200 mmol/l).
6. liver disease (AST, ALT, GGT> 3 x ULN).
7. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. The platelet reactivity index<br /><br>2. The inhibition of platelet aggregation</p><br>
- Secondary Outcome Measures
Name Time Method <p>Side effects of pantoprazole.</p><br>