The Effects of Exercise Program in Alzheimer's Patients With Mild to Moderate Stage Alzheimer's Disease
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Dokuz Eylul University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Change in cognition
Study Overview
Brief Summary
The primary aim of this trial is to investigate the feasibility of an exercise program consisting of respiratory exercises, aerobic exercises and strengthening exercises in mild to moderate Alzheimer's disease. The trial also aims to investigate the effectiveness of the exercise program on respiratory symptoms, exercise capacity, cognition, physical performance, depression, sleepiness, activities of daily living and quality of life.
Patients will be divided into exercise (intervention) and control group by randomization method. The study is planned to be performed with a total of 60 patients, 30 in each group. The patients in the exercise group will be given breathing exercises aerobic exercises and strengthening exercises for 2 days a week for 12 weeks, about 30-40 minutes while the patients in the control group will be provided with suggestions, home exercise program and daily life activities
Detailed Description
Exercise group was trained 3 times a week under the supervision of a physiotherapist and encouraged to exercise at home on other days
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Masking Description
An assessor who was blinded to treatment groups assessed clinical outcomes before the treatment process. The same assessor was also repeated assessments at 13th week (at the end of treatment process)
Eligibility Criteria
- Ages
- 65 Years to — (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •aged over 65 years
- •can walk independent
Exclusion Criteria
- •can't see
- •have done any exercise in the last 6 months
- •have a major and uncontrolled orthopedic, neurological or cardiopulmonary problem that restricts functioning
- •having non Alzheimer's disease dementia
Arms & Interventions
Exercise Group
Intervention: Exercise (Other)
Control
Intervention: Exercise (Other)
Outcomes
Primary Outcomes
Change in cognition
Time Frame: Baseline, 12th week
The Mini-Mental State Examination (MMSE) is used to measure cognitive impairment in older adults. It assesses different subset of cognitive status including attention, language, memory, orientation, visuospatial proficiency.
Secondary Outcomes
- Change in physical performance(Baseline, 12th week)
- Change in pulmonary functions(Baseline, 12th week)
- Change in respiratory muscle strength(Baseline, 12th week)
- Change in functional capacity(Baseline, 12th week)
- Change in sleepiness(Baseline, 12th week)
- Change in quality of life(Baseline, 12th week)
- Change in activities of daily living(Baseline, 12th week)
- Change in depression(Baseline, 12th week)
- Change in muscle strength(Baseline, 12th week)
Investigators
Elvan Keles
Research Assistant
Dokuz Eylul University