Hemodynamic and Biochemical Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- delayed cerebral ischemia
研究概览
简要总结
The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI. Assessment of cerebral autoregulation with transcranial Doppler (TCD) may improve the prediction of DCI. The aim of this prospective study was to assess the value of TCD-derived variables to be used alone or in combination for prediction of DCI
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Group 1 : • Patients who presented a ruptured aneurysm by aneurysmal subarachnoid hemorrhage (SAH) older than 72 hours. Diagnosis of SAH was confirmed by computed tomography, magnetic resonance imaging (MRI) or lumbar puncture as recommended
- •symptomatic aneurysm treated with endovascular,
- •Absence of achieving a lumbar puncture,
- •Patients affiliated to a social security scheme,
- •Patients who have given their free and informed consent and signed the consent or consent of the family.
- •healthy volunteers with cerebrospinal fluid sample
排除标准
- •Patients with no readable acoustic temporal bone window
- •Patients with previous disease that might impair cerebral autoregulation (e.g., carotid stenosis, history of stroke or head injury).
研究组 & 干预措施
Patients with subarachnoid hemorrhage
Patients with subarachnoid hemorrhage will have CerebroSpinal fluid and plasma sample.
干预措施: CerebroSpinal fluid and plasma samples (Procedure)
Control subjects
healthy controls from a previous study with a CerebroSpinal fluid and plasma sample
干预措施: CerebroSpinal fluid and plasma samples (Procedure)
结局指标
主要结局
delayed cerebral ischemia
时间窗: inclusion
DCI was confirmed by CT or MR imaging
次要结局
未报告次要终点