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Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage

Not Applicable
Completed
Conditions
Ischemia
Registration Number
NCT02829398
Lead Sponsor
University Hospital, Toulouse
Brief Summary

The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI. Assessment of cerebral autoregulation with transcranial Doppler (TCD) may improve the prediction of DCI. The aim of this prospective study was to assess the value of TCD-derived variables to be used alone or in combination for prediction of DCI

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
41
Inclusion Criteria

Group 1 : • Patients who presented a ruptured aneurysm by aneurysmal subarachnoid hemorrhage (SAH) older than 72 hours. Diagnosis of SAH was confirmed by computed tomography, magnetic resonance imaging (MRI) or lumbar puncture as recommended

  • symptomatic aneurysm treated with endovascular,
  • Absence of achieving a lumbar puncture,
  • Patients affiliated to a social security scheme,
  • Patients who have given their free and informed consent and signed the consent or consent of the family.

Group 2 :

healthy volunteers with cerebrospinal fluid sample

Exclusion Criteria
  • Patients with no readable acoustic temporal bone window
  • Patients with previous disease that might impair cerebral autoregulation (e.g., carotid stenosis, history of stroke or head injury).

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
delayed cerebral ischemiainclusion

DCI was confirmed by CT or MR imaging

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

University Hospital of Toulouse

🇫🇷

Toulouse, France

University Hospital of Toulouse
🇫🇷Toulouse, France

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