Effect of inflammation on the stratum corneum lipid biosynthesis in the skin barrier of atopic eczema patients

• Conditions: Atopic dermatitis; neurodermitis; 10014982

• Registration Number: NL-OMON42915
• Lead Sponsor: niversiteit Leiden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

(page 13 research protocol)
- Aged between 18 and 40 years;
- Caucasian.

Exclusion Criteria

(page 14 research protocol)
- Aged under 18 or over 40;
- Non-Caucasian;
- Abundant hair presence on the ventral forearms;
- Unnatural abnormalities on one of their ventral forearms (e.g. skin lesions, tattoos);
- Using any systemic drug therapy (e.g. cholesterol-lowering drugs, insulin related drugs, steroids and immunosuppressants);
- Who received phototherapy in the past 2 years
- Pregnancy
Additional exclusion criteria for healthy subjects:
- No chronically inflammatory disease;
- Use of dermatological products (e.g. creams) on their ventral forearms on a daily basis.
- Dermatological disorders or a history of dermatological disorders

Additional exclusion criteria for AE patients:
- The absence of both lesional and non-lesional skin sites on their ventral forearms at day 0 of the study.
- The use of corticosteroids class IV or higher. Patients with corticosteroids class I-III need to give informed consent about changing their medication to a standardized regimen (see protocol page 11-13).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified