Targeted Decision Making In Renal Cell Carcinoma Relying on a Radiogenomics Translational Platform
- Conditions
- Renal Tumors
- Registration Number
- NCT06868927
- Lead Sponsor
- IRCCS San Raffaele
- Brief Summary
This project aims to provide an accurate strategy to guide the decision making relying on tumor biopsies using standard histology, immunohistochemistry (IHC), spatial transcriptomics, genomics combined with Magnetic Resonance Imaging (MRI) and radiomics. Moreover, the investigators will explore potential markers indicative of response to systemic agents or ablative therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Presence of a renal mass up to 4 cm
- Adult > 18 years
- Candidate to renal surgery
- Informed consent signed
- Contraindication for MRI
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method accuracy of multiparametric preoperative MRI At final pathological assessment , at least 1 month after surgery Detection of "Unfavourable outcome" is defined as the presence of at least one of the following pathological characteristics:
* High grade tumor (G3 or G4)
* Not-organ confined disease (pT3 and or pT4 and/or LNI)
* Sarcomatoid features
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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