A Comparitive study of Oral Apremilast and Oral Minipulse Betamethasone therapy in Alopecia Areata : A Trichoscopic assessment of treatment outcomes
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- This study will measure hair regrowth in patients of alopecia areata after treatment with Oral apremilast and oral minipulse Betamethasone and signs noted on trichoscopy and improvement in SALT Score after completing 12 weeks of treatment
研究概览
简要总结
It is a study to evaluate the efficacy safety and adverse effects of Oral Apremilast and oral minipulse betamethasone in patients of lipecia areata. A 3month follow up will be done and results will be compared from baseline using trichoscopy with proper consent . Relevant investigations will be done before starting the drugs . Treatment will be started at the dermatologist’s discretion and will be observed by the primary investigtor with a monthly follow up for 3 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients willing to give consent.
- •Patients of alopecia areata with more than equal to 3 patches or scalp area involving more than 10% .
排除标准
- •Patients who have received topical and systemic medications for alopecia areata upto 1 month before.
- •Pregnant and lactating women.
- •Patients with history of active TB or incompletely treated TB.
- •Patients with psychiatric illness.
- •Patients with HIV, Hepatitis B and Malignancy.
- •History of serious side effects to phosphodiesterase type 4 inhibitors – Apremilast.
- •Patients with severe renal impairment, hepatic impairment cardiac diseases.
结局指标
主要结局
This study will measure hair regrowth in patients of alopecia areata after treatment with Oral apremilast and oral minipulse Betamethasone and signs noted on trichoscopy and improvement in SALT Score after completing 12 weeks of treatment
时间窗: 12 weeks
次要结局
- Check for any adverse effects(4weeks ,8weeks & 12 weeks)
研究者
Vaishnavi Puri
Kasturba Medical college Mangalore