Prevalence of Major Depression Among Immigrants in Santiago, Chile

Completed

• Conditions: Major Depressive Disorder

• Registration Number: NCT04114565
• Lead Sponsor: Pontificia Universidad Catolica de Chile

Brief Summary

The general aim of this study is to explore the prevalence of major depressive disorder and the use of mental health services in the immigrant populations in the Metropolitan Region of Santiago, Chile.

The hypotheses are:

1. A healthy immigrant effect will be observed in the studied population by which their prevalence of major depressive disorder will be lower than the prevalence in the general Chilean population.

2. A significant association will be observed between the loss of socio-economic position after migration and a greater probability of major depressive disorder.

3. A significant association will be observed between the report of victimization experience(s) in the previous year and a greater probability of major depressive disorder.

4. A significant association will be observed between financial difficulties and a greater probability of major depressive disorder.

The sampling framework of the Chilean National Institute of Statistics (INE) from the 2016 Census will be used for the purpose of this research. The sampling units are as follows:

1. Primary sampling units (PSUs): conglomerates or groups of adjoining houses, organized in spatial blocks (200 households on average)

2. Secondary sampling units (SSUs): individual households within each of the conglomerates selected in the first stage

3. Final sampling units: persons meeting the study's inclusion criteria Multi-stage random probability sampling involving a 3-stage sampling design will be used - first, the sampling of the primary sampling units (PSUs); second, the sampling of households within the selected PSUs and finally, the random sampling of a household member.

Participants (n=1,100) will then take part in a 45-minute interview. This interview will be a household survey using the modular version of the Composite International Diagnostic Interview (WHO-CIDI) looking at exploring a broad spectrum of factors traditionally associated with increased risk of affective disorders:

1. Sociodemographics

2. Finance

3. Variation in socioeconomic position

4. Experience of victimization

5. Discrimination

6. Experience of childhood adversity

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-29
• Study First Submitted: 2019-09-30
• Study First Submitted QC: 2019-10-02
• Study First Posted: 2019-10-03
• Primary Completion: 2019-11-30
• Study Completion: 2020-06-30
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-29
• Last Update Posted: 2020-07-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1092

Inclusion Criteria

• Country of birth other than Chile
• Time since arrival to Chile: 3 months

Exclusion Criteria

• Unable to understand Spanish

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Major Depressive Disorder	baseline	Assessed using the World Health Organisation Composite International Diagnostic Interview (WHO-CIDI)
Anxiety symptoms	baseline	Assessed using the Generalized Anxiety Disorder 7-item scale (GAD-7).; The GAD-7 score can range from 0 to 21, with the following severity scores: 0-4 None; 5-9 Mild; 10-14 Moderate; 15-21 Severe.
Any affective/mood disorder	baseline	Assessed using the WHO-CIDI
Suicidal ideation, plans and attempts	baseline	Assessed using the WHO-CIDI
Depressive symptoms	baseline	Assessed using the nine-item Patient Health Questionnaire (PHQ-9).; The PHQ-9 score can range from 0 to 27, with the following severity scores: 0-4 None; 5-9 Mild; 10-14 Moderate; 15-19 Moderate to Severe; 20-27 Severe.

Secondary Outcome Measures

Name	Time	Method
Hazardous/harmful drinking	baseline	Assessed using the Alcohol Use Disorders Identification Test (AUDIT)
Mental wellbeing	baseline	Assessed using the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS).; The 14 Items are scored on a range from 1 to 5, providing a total score between 14 and 70 with higher values indicating higher mental well-being.
Mental health service use	baseline	Assessed using items of the Services Module of the WHO-CIDI

Trial Locations

Locations (1)

Pontificia Universidad Catolica de Chile; 🇨🇱 Santiago, RM, Chile