Ayurvedic management of coronary artery diseases

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1. Both sex

2. Age group between 20-70 years

3. Class I, II&IIa (III) as per Canadian Cardiovascular Society grading of angina pectoris

4.CAC Scoring < 400/ <90 percentile

5. ECG- T wave inverted without Q wave / ST elevation

6.Stress TMT- Positive

7. Angiography- <60% occlusion in any of the coronary artery

8. Those are able to give written consent

Exclusion Criteria

1.Renal insufficiency (S. Creatinine > 2 mg/dl, Blood Urea > 40 mg/dl)

2.Ã¢?•2D ECHO showing the presence of any valvular heart disease

3.Tachycardia( >160/min)/ Ventricular arrhythmia

4. Low Left Ventricular Ejection Fraction (LVEF < 40%)

4.Ã¢?•Positive Troponin Test

5.CT Angiography lesion > 60%

6.Ã¢?•CPK-MB > 5%

7. Prolonged or traumatic cardiovascular resuscitation

8. Previous Coronary Intervention (within 3 months) or any bypass surgery

9. Ischemic Cerebral stroke within past one months

10. Peripheral arterial diseases

11. Recent Head trauma or known intracranial neoplasm

12. Suspected aortic dissection

13. Prolonged chest pain ( > 30mints) associated with vomiting and syncope

14. Chest pain with vagotonia (bradycardia, pallor, and syncope)

15. Haemorrhagic stroke within past one month

16. Diabetic haemorrhagic retinopathy or other haemorrhagicopthalamic conditions.

17. Recorded uncontrolled Blood Pressure >180/100mmHg in three consecutive readings

18. Active peptic ulcer

19. Significant liver dysfunction

20.Ã¢?•Raised Prothrombin time, Activated Partial Thromboplastin Time

21.Ã¢?•Heart failure (Brain Natriuretic Peptide > 2 times)

22. Active bleeding, Known bleeding diathesis or current use of anticoagulant

23. BMI <18

24. All VirechanAnarha patients as mentioned in Ch. Si 2/11 will be excluded

VirechanAnarha are Subhag, Kshatgud, Muktanal, Adhog Raktapitta, Vilanghit,Durbal, Alpagni, Adivya nirudhaka, Ajirna, Nawajwar, Madatyay, Aadhman, Shalyadrit, Atisnigdha, Atiruksha, Krurkoshtha, Urahkshat, Kshina, Atisthul, Atikrusha, Garbhini.

Any other case if investigator feels could not include in the study during the course of study

(Ã¢?• Investigation will be done if feasible)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Cardiac computed tomography angiography (CCTA)Timepoint: 3 months

Secondary Outcome Measures

Name	Time	Method
Change in followings- <br/ ><br>1.Change in coronary artery calcium scoring. <br/ ><br>2.Change in stress TMT. <br/ ><br>3.Change in Chest Pain/ Discomfort Questionnaires, <br/ ><br>4.SF-36 <br/ ><br>5.BODE Index. <br/ ><br>Timepoint: 3 months