Incidence of hypertensive response during endotracheal intubation between supplement intravenous bolus propofol and sevoflurane: A prospective randomized-controlled trial

Phase 4

Recruiting

• Conditions: Blood pressure and heart rate after tracheal intubation; Hypertensive response, Intubation, Propofol, Sevoflurane

• Registration Number: TCTR20220117005
• Lead Sponsor: Faculty of Medicine, Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-01-29
• Study Start: 2022-01-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

Adult 18-65 years
ASA physical status I-II

Exclusion Criteria

SBP baseline < 100 mmHg and/or HR < 50 bpm.
BMI > 30kg/m2
Anticipated difficult intubation
Risk aspiration
Patients with severe cardiovascular diseases
Contraindication for propofol, fentanyl, cisatracurium and sevoflurence
Abnormal EKG: bradycardia < 50 bpm, second to third degree AV block, LBBB, ST-T change that indicate MI

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of hypertensive response after tracheal intubation 5 min after tracheal intubation Ratio

Secondary Outcome Measures

Name	Time	Method
Blood pressure and heart rate pre-intubation 5 min after intubation Mean,Adverse effect and vasoactive agents used among pre- intubation and post-intubation 5 min after intubation Percentage