Study of Ozanimod (RPC1063) in Relapsing Multiple Sclerosis (MS)
- Conditions
- Multiple Sclerosis
- Interventions
- Registration Number
- NCT02294058
- Lead Sponsor
- Celgene
- Brief Summary
The purpose of this study is to determine whether ozanimod is effective in the treatment of relapsing multiple sclerosis (RMS).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1346
- Multiple sclerosis as diagnosed by the revised 2010 McDonald criteria
- EDSS score between 0 and 5.0 at baseline
• Primary progressive multiple sclerosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Interferon beta-1a Placebo to ozanimod Participants received 30 µg interferon beta-1a by intramuscular (IM) injection weekly and matching placebo capsules (identical in physical appearance to ozanimod) orally once a day until the last participant had been treated for 12 months. Ozanimod 0.5 mg Placebo to interferon beta-1a Participants received ozanimod 0.5 mg capsules orally once a day and an intramuscular placebo injection (identical in appearance to Interferon) weekly until the last participant had been treated for 12 months. Ozanimod 1 mg Placebo to interferon beta-1a Participants received ozanimod 1 mg capsules orally once a day and an intramuscular placebo injection (identical in appearance to Interferon) weekly until the last participant had been treated for 12 months. Interferon beta-1a Interferon beta-1a Participants received 30 µg interferon beta-1a by intramuscular (IM) injection weekly and matching placebo capsules (identical in physical appearance to ozanimod) orally once a day until the last participant had been treated for 12 months. Ozanimod 0.5 mg Ozanimod Participants received ozanimod 0.5 mg capsules orally once a day and an intramuscular placebo injection (identical in appearance to Interferon) weekly until the last participant had been treated for 12 months. Ozanimod 1 mg Ozanimod Participants received ozanimod 1 mg capsules orally once a day and an intramuscular placebo injection (identical in appearance to Interferon) weekly until the last participant had been treated for 12 months.
- Primary Outcome Measures
Name Time Method Adjusted Annualized Relapse Rate (ARR) During the Treatment Period 12 months The relapse rate was based on confirmed relapses. A relapse was defined as new or worsening neurological symptoms attributable to MS and preceded by a relatively stable or improving neurological state for at least 30 days. Symptoms must have persisted for \> 24 hours and not be attributable to confounding clinical factors. Relapses were confirmed when accompanied by objective neurological worsening based on examination by the blinded evaluator, consistent with an increase of ≥ 0.5 on the overall EDSS score relative to the most recent EDSS assessment, or 2 points on one of the functional system scale scores, or 1 point on ≥ two functional system scale scores.
Relapse rate was calculated as the total number of relapses divided by the total number of days in the study \* 365.25.
ARR was adjusted for region (Eastern Europe vs rest of world), Baseline age, and Baseline number of gadolinium-enhancing lesions; the natural log transformation of time on study was included as an offset term.
- Secondary Outcome Measures
Name Time Method Adjusted Mean Number of New or Enlarging Hyperintense T2-Weighted Brain Magnetic Resonance Imaging (MRI) Lesions Per Scan Over 12 Months 12 month treatment period; MRI scans were assessed at Month 6 and Month 12 The number of new or enlarging hyperintense T2-weighted brain MRI lesions per scan was based on the cumulative number of new or enlarging T2 lesions since Baseline over treatment period.
Adjusted Mean Number of Gadolinium Enhancing (GdE) Brain MRI Lesions at Month 12 Month 12 Time to Onset of Disability Progression Confirmed After 6 Months From first dose to the end of the 12-month treatment period EDSS is used to quantify disability and disability progression over time in MS. Based on a neurological examination, 8 functional systems (visual, brain stem, pyramidal, cerebellar, sensory, bowel \& bladder, cerebral, and other functions) are scored from 0 (no disability) to 5 or 6 (more severe disability). Ambulation is assessed based on distance the patient is able to walk, whether assistance is required or restrictions are present.
The EDSS score ranges from 0 (normal) to 10 (death due to MS) in 0.5 unit increments.
Disability progression is defined by a sustained worsening in EDSS score of 1.0 point or more confirmed after 6 months. Time to onset of disability progression was calculated from the date of first dose to the date of the first visit at which the 1.0 point increase in EDSS was met using Kaplan-Meier methods. Participants without a sustained disease progression event were censored on the date of their last assessment or last dose of study drug, whichever was later.Time to Onset of Disability Progression Confirmed After 3 Months From first dose to the end of the 12-month treatment period EDSS is used to quantify disability and disability progression over time in MS. Based on a neurological examination, 8 functional systems (visual, brain stem, pyramidal, cerebellar, sensory, bowel \& bladder, cerebral, and other functions) are scored from 0 (no disability) to 5 or 6 (more severe disability). Ambulation is assessed based on distance the patient is able to walk, whether assistance is required or restrictions are present.
The EDSS score ranges from 0 (normal) to 10 (death due to MS) in 0.5 unit increments.
Disability progression is defined by a sustained worsening in EDSS score of 1.0 point or more confirmed after 3 months. Time to onset of disability progression was calculated from the date of first dose to the date of the first visit at which the 1.0 point increase in EDSS was met using Kaplan-Meier methods. Participants without a sustained disease progression event were censored on the date of their last assessment or last dose of study drug, whichever was later.Percentage of Participants Who Were T2 Lesion-Free at Month 12 Month 12 MRI scans were analyzed by blinded centralized reading facility.
Percent Change From Baseline in Normalized Brain Volume at Month 12 Baseline to Month 12 Brain volume (a measure of brain atrophy) was analyzed by MRI.
Percentage of Participants Who Were Gadolinium Enhancing Lesion-Free at Month 12 Month 12 MRI scans were analyzed by blinded centralized reading facility.
Change From Baseline to Month 12 in Multiple Sclerosis Functional Composite (MSFC) Score Including the Low-Contrast Letter Acuity (LCLA) Test Baseline to Month 12 The MSFC-LCLA is a battery including the following 4 individual scales:
* Timed 25-Foot Walk is an ambulation measure of walking 25 feet with time taken recorded in seconds
* 9-Hole Peg Test (9HPT) is a quantitative measure of upper extremity (arm and hand) function
* Symbol Digit Modalities Test (SDMT) is a measure of executive cognitive function that assesses processing speed, flexibility, and calculation ability
* Low-Contrast Letter Acuity Test (LCLA) used a standardized set of charts to assess low contrast visual acuity, charts are scored according to the number of letters that are identified correctly
Z-scores were calculated for for each component and averaged to create an overall composite score, using the study population as the reference population. A z-score represents the number of standard deviations a patient's test result is higher (z \> 0) or lower (z \< 0) than the average test result (z = 0) of the reference population. A positive change indicates improvement.Mean Change From Baseline in Multiple Sclerosis Quality of Life (MSQOL)-54 Physical Health Composite Summary and Mental Health Composite Summary Scores Baseline to Month 12 The MSQOL-54 is a multidimensional health-related QOL measure that combines both generic and MS-specific items into a single instrument. The instrument includes 12 subscales, two summary scores, and two single-item measures.
The two summary scores - physical health and mental health - are derived from a weighted combination of scale scores.
The physical health composite score includes Physical function, Health perceptions, Energy/fatigue, Role limitations - physical, Pain, Sexual function, Social function, and Health distress.
The mental health composite score includes Health distress, Overall quality of life, Emotional well-being, Role limitations - emotional, and Cognitive function.
Each composite summary score has a range from 0 to 100 where higher scores indicate better quality of life. A positive change from Baseline indicates improvement.Number of Participants With Treatment Emergent Adverse Events From the first dose of study drug until 28 days following the last dose of study drug; mean exposure to study drug was 13.5 months for interferon beta-1a and 13.6 months for each ozanimod group. An adverse event (AE) is any untoward medical occurrence that does not necessarily have a causal relationship with the investigational product (IP). An AE can be any unfavorable or unintended sign, including an abnormal laboratory finding, symptom or disease temporally associated with the use of an IP whether or not considered related to the IP. A serious AE (SAE) is any untoward medical occurrence or effect that results in death, is life-threatening, requires hospitalization or prolongation of existing inpatient hospitalization. The investigator assessed the severity of AEs as mild, moderate, or severe.
Trial Locations
- Locations (223)
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Neurological Research Institute Inc
🇺🇸Columbus, Ohio, United States
The Polyclinic
🇺🇸Seattle, Washington, United States
Northwest Neuro Specialists PLLC
🇺🇸Tucson, Arizona, United States
Alta Bates Summit Medical Center
🇺🇸Berkeley, California, United States
Collaborative Neuroscience Network Inc
🇺🇸Long Beach, California, United States
University of California Davis Medical Center
🇺🇸Sacramento, California, United States
Infinity Clinical Research LLC
🇺🇸Pompano Beach, Florida, United States
Neurology Associates PA
🇺🇸Maitland, Florida, United States
Neurostudies Inc
🇺🇸Port Charlotte, Florida, United States
Roskamp Institute
🇺🇸Sarasota, Florida, United States
Consultants In Neurology
🇺🇸Northbrook, Illinois, United States
West Georgia Sleep Disorder Center and Neurology Associates
🇺🇸Douglasville, Georgia, United States
Associates In Neurology
🇺🇸Lexington, Kentucky, United States
Norton Healthcare
🇺🇸Louisville, Kentucky, United States
Washington University
🇺🇸Saint Louis, Missouri, United States
Neurology Specialists of Monmouth County PA
🇺🇸West Long Branch, New Jersey, United States
Neuro Medical Care Associates PLLC
🇺🇸Johnson City, New York, United States
Raleigh Neurology Associates PA
🇺🇸Raleigh, North Carolina, United States
Neurology and Neuroscience Associates Inc.
🇺🇸Akron, Ohio, United States
University of Texas Health Science Center at Houston
🇺🇸Houston, Texas, United States
EvergreenHealth
🇺🇸Kirkland, Washington, United States
Bhupesh Dihenia MD PA
🇺🇸Lubbock, Texas, United States
Neurology of Neurosurgery Associates of Tacoma
🇺🇸Tacoma, Washington, United States
Grodno Clinical Regional Hospital
🇧🇾Grodno, Belarus
Minsk City Clinical Hospital 9
🇧🇾Minsk, Belarus
Vitebsk Regional Clinical Hospital
🇧🇾Vitebsk, Belarus
Clinical Center University of Sarajevo
🇧🇦Sarajevo, Bosnia and Herzegovina
Clinical Center Banja Luka
🇧🇦Banja Luka, Bosnia and Herzegovina
University Clinical Center Tuzla
🇧🇦Tuzla, Bosnia and Herzegovina
Multiprofile Hospital for Active Treatment National Cardiology Hospital EAD
🇧🇬Sofia, Bulgaria
Multiprofile Hospital for Active Treatment Tokuda Hospital Sofia
🇧🇬Sofia, Bulgaria
Multiprofile Hospital for Active Treatment Sveta Marina EAD
🇧🇬Varna, Bulgaria
General Hospital Varazdin
🇭🇷Varazdin, Croatia
Fakultni nemocnice u sv Anny v Brne
🇨🇿Brno, Czechia
Private Neurological Practice Radomir Talab MD
🇨🇿Hradec Kralove, Czechia
University Hospital Brno
🇨🇿Brno, Czechia
University Hospital Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Nemocnice Jihlava prispevkova organizace
🇨🇿Jihlava, Czechia
Fakultni Nemocnice Olomouc
🇨🇿Olomouc, Czechia
Krajska zdravotni as Nemocnice Teplice oz
🇨🇿Teplice, Czechia
Vseobecna Fakultni Nemocnice v Praze
🇨🇿Praha 2, Czechia
East Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Aversi Clinic LTD
🇬🇪Tbilisi, Georgia
Curatio JSC
🇬🇪Tbilisi, Georgia
Pauls Stradins Clinical University Hospital
🇱🇻Riga, Latvia
St. Joseph Krankenhaus Berlin
🇩🇪Berlin, Germany
Asklepios Fachklinikum Teupitz
🇩🇪Brandenburg, Germany
Universitatsklinikum Carl Gustav Carus an der TU Dresden
🇩🇪Dresden, Germany
Heinrich Heine Universitat Dusseldorf
🇩🇪Düsseldorf, Germany
DataMed GmbH
🇩🇪Köln, Germany
Universitatsklinikum Leipzig
🇩🇪Leipzig, Germany
St. Josefs-Krankenhaus Potsdam-Sanssouci GmbH
🇩🇪Potsdam, Germany
Klinikum der Philipps Universitat Marburg
🇩🇪Marburg, Germany
Krankenhaus der Barmherzigen Brueder
🇩🇪Trier, Germany
NeuroPoint Akademie
🇩🇪Ulm, Germany
Klinikum der Stadt Ludwigshafen gGmbH
🇩🇪Ludwigshafen am Rhein, Germany
Kenezy Gyula Korhaz es Rendelointezet
🇭🇺Debrecen, Hungary
Pest Megyei Flor Ferenc Korhaz
🇭🇺Kistarcsa, Hungary
Klaipeda University Hospital
🇱🇹Klaipeda, Lithuania
IMSP Institutul de Medicina Urgenta
🇲🇩Chisinau, Moldova, Republic of
Municipal Clinical Hospital Sf Arhanghel Mihail
🇲🇩Chisinau, Moldova, Republic of
Auckland City Hospital
🇳🇿Auckland, New Zealand
Christchurch Hospital
🇳🇿Christchurch, New Zealand
Institutul de Neurologie si Neurochirurgie
🇲🇩Chisinau, Moldova, Republic of
Waikato Hospital
🇳🇿Hamilton, New Zealand
Powiatowy Zespol Zakladow Opieki Zdrowotnej Szpital w Czeladzi
🇵🇱Czeladz, Poland
Copernicus Podmiot Leczniczy Sp. z o.o.
🇵🇱Gdansk, Poland
Novo-Med Zielinski i wsp. Sp.J.
🇵🇱Katowice, Poland
M.A.- Lek A.M.Maciejowscy Spolka Cywilna
🇵🇱Katowice, Poland
RESMEDICA Spolka z o.o.
🇵🇱Kielce, Poland
NZOZ NEUROMED M. I M. Nastaj Spolka Partnerska
🇵🇱Lublin, Poland
Samodzielny Publiczny Centralny Szpital Kliniczny
🇵🇱Mazowieckie, Poland
Neurologiczny NZOZ Centrum Leczenia SM Osrodek Badan Klinicznych Dr n med Hanka Hertmanowska
🇵🇱Plewiska, Poland
Indywidualna Specjalistyczna Praktyka Lekarska dr nmed Monika Lyczak
🇵🇱Pomorskie, Poland
SPZOZ Wojewodzki Szpital Specjalistyczny nr 3 w Rybniku
🇵🇱Rybnik, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
Centrum Medyczne NeuroProtect
🇵🇱Warszawa, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Centro Hospitalar E Universitario de Coimbra EPE
🇵🇹Coimbra, Portugal
Hospital Garcia de Orta
🇵🇹Almada, Portugal
Hospital Beatriz Angelo
🇵🇹Loures, Portugal
Colentina Clinical Hospital
🇷🇴Bucharest, Romania
Bryansk Regional Hospital 1
🇷🇺Bryansk, Russian Federation
Chelyabinsk City Clinical Hospital 3
🇷🇺Chelyabinsk, Russian Federation
Sverdlovsk Regional Clinical Hospital 1
🇷🇺Ekaterinburg, Russian Federation
Krasnoyarsk State Medical Academy
🇷🇺Krasnoyarsk, Russian Federation
Research Medical Complex Vashe Zdorovie
🇷🇺Kazan, Russian Federation
Kemerovo Regional Clinical Hospital
🇷🇺Kemerovo, Russian Federation
Central Clinical Hospital 2 na NA Semashko OAO RZhD
🇷🇺Moscow, Russian Federation
City Clinical Hospital 24
🇷🇺Moscow, Russian Federation
City Clinical Hospital 11
🇷🇺Moscow, Russian Federation
Nizhniy Novgorod City Hospital 33
🇷🇺Nizhny Novgorod, Russian Federation
City Clinical Hospital 3 Nizhniy Novgorod Geriatrics Centre
🇷🇺Nizhny Novgorod, Russian Federation
Novosibirsk State Medical University
🇷🇺Novosibirsk, Russian Federation
Perm State Medical Academy
🇷🇺Perm, Russian Federation
Republican Hospital na VA Baranov
🇷🇺Petrozavodsk, Russian Federation
City Hospital 31
🇷🇺St. Petersburg, Russian Federation
Smolensk State Medical Academy
🇷🇺Smolensk, Russian Federation
Siberian State Medical University
🇷🇺Tomsk, Russian Federation
Institute of Human Brain RAN
🇷🇺St. Petersburg, Russian Federation
Neftyanik Medical and Sanitary Unit
🇷🇺Tyumen, Russian Federation
Kuvatov Republican Clinical Hospital
🇷🇺Ufa, Russian Federation
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Clinical Hospital Centar Zvezdara
🇷🇸Belgrade, Serbia
Military Medical Academy
🇷🇸Belgrade, Serbia
Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
Hospital Arnau de Vilanova
🇪🇸Lleida, Spain
Hospital Universitario Vall D hebron
🇪🇸Barcelona, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Complejo Hospitalario de Navarra
🇪🇸Pamplona/ Navarra, Spain
Hospital Moises Broggi
🇪🇸Sant Joan Despí, Spain
Sahlgrenska Universitetssjukhuset
🇸🇪Goteborg, Sweden
Hospital 4 of Chernihiv City Council
🇺🇦Chernihiv, Ukraine
State Treatment and Prevention Institution Central Clinical Hospital of Ukrzaliznytsya
🇺🇦Kharkiv, Ukraine
Regional Clinical Hospital.
🇺🇦Ivano Frankivsk, Ukraine
Volyn Regional Clinical Hospital
🇺🇦Lutsk, Ukraine
Municipal Institution of Health Care Kharkiv Clinical City Hospital 7
🇺🇦Kharkiv, Ukraine
Center for Reconstructive and Rehabilitation Medicine University Clinic of ONMedU
🇺🇦Odesa, Ukraine
Regional Clinical Hospital na NV Sklifosovskyi
🇺🇦Poltava, Ukraine
Municipal City Clinical Hospital 5
🇺🇦Lviv, Ukraine
Regional Clinical Center of Neurosurgery and Neurology
🇺🇦Uzhhorod, Ukraine
Municipal Institution City Clinical Hospital 2
🇺🇦Zaporizhya, Ukraine
Regional Clinical Hospital na OFHerbachevskyi of Zhytomyr Regional Council
🇺🇦Zhytomyr, Ukraine
University Hospital of Wales
🇬🇧Cardiff, United Kingdom
Raigmore Hospital
🇬🇧Inverness, United Kingdom
Kings College Hospital
🇬🇧London, United Kingdom
Royal Hallamshire Hospital Sheffield Teaching Hospitals NHS Trust
🇬🇧Sheffield, United Kingdom
MidAmerica Neuroscience Research Foundation
🇺🇸Lenexa, Kansas, United States
Minneapolis Clinic of Neurology
🇺🇸Golden Valley, Minnesota, United States
Kirov City Clinical Hospital 1
🇷🇺Kirov, Russian Federation
Michigan State University
🇺🇸East Lansing, Michigan, United States
Cleveland Clinic Lou Ruvo Center for Brain Health
🇺🇸Las Vegas, Nevada, United States
Vitebsk Regional Diagnostic Centre
🇧🇾Vitebsk, Belarus
West Tallinn Central Hospital
🇪🇪Tallinn, Estonia
LTD MediClubGeorgia
🇬🇪Tbilisi, Georgia
Zuyderland Medisch Centrum
🇳🇱Sittard-Geleen, Netherlands
B&B Robert Bonek, Pawel Bochniak, Spolka Cywilna
🇵🇱Bydgoszcz, Poland
Niepubliczny Zaklad Opieki Zdrowotnej NEURO-MEDIC
🇵🇱Katowice, Poland
Niepubliczny Zespol Leczniczo-Rehabilitacyjny Centrum Kompleksowej Rehabilitacji
🇵🇱Konstancin Jeziorna, Poland
Centrum Neurologii Krzysztof Selmaj
🇵🇱Lódzkie, Poland
Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv Naum EAD
🇧🇬Sofia, Bulgaria
Clinical Hospital Sveti duh
🇭🇷Zagreb, Croatia
Khechinashvili University Hospital
🇬🇪Tbilisi, Georgia
NEURO- CARE Site Management Organization Gabriela Klodowska-Duda
🇵🇱Katowice, Poland
Fundeni Clinical Institute
🇷🇴Bucharest, Romania
Belgorod Regional Clinical Hospital
🇷🇺Belgorod, Russian Federation
Pyatigorsk City Hospital 2
🇷🇺Pyatigorsk, Russian Federation
St. Petersburg Multi Field City Hospital 2
🇷🇺St. Petersburg, Russian Federation
Yaroslavl Clinical Hospital 8
🇷🇺Yaroslavl, Russian Federation
Clinical Hospital Centre Zemun
🇷🇸Belgrade, Serbia
Municipal Treatment and Preventive Institution Chernihiv Regional Clinical Hospital
🇺🇦Chernihiv, Ukraine
City Clinical Hospital 1 na NIPirogov
🇷🇺Moscow, Russian Federation
Minsk Municipal Clinical Hospital 5
🇧🇾Minsk, Belarus
Republican Scientific and Practical Centre of Neurology and Neurosurgery
🇧🇾Minsk, Belarus
University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD
🇧🇬Sofia, Bulgaria
Clinical Hospital Osijek
🇭🇷Osijek, Croatia
Clinique Neuro Outaouais
🇨🇦Gatineau, Quebec, Canada
Military Medical Academy - MHAT
🇧🇬Sofia, Bulgaria
Clinical Hospital Center Zagreb
🇭🇷Zagreb, Croatia
Clinical Hospital Dubrava
🇭🇷Zagreb, Croatia
Clinical Hospital Sestre Milosrdnice
🇭🇷Zagreb, Croatia
Sarajishvili Institute of Neurology
🇬🇪Tbilisi, Georgia
Ltd DEKA
🇬🇪Tbilisi, Georgia
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
🇱🇹Kaunas, Lithuania
Niepubliczny Zaklad Opieki Zdrowotnej NEUROKARD Ilkowski i Partnerzy Spolka Partnerska Lekarzy
🇵🇱Poznan, Poland
Sibiu Emergency County Clinical Hospital
🇷🇴Sibiu, Romania
Timisoara Emergency County Clinical Hospital
🇷🇴Timisoara, Romania
Arkhangelsk Regional Clinical Hospital
🇷🇺Arkhangelsk, Russian Federation
Regional Clinical Hospital
🇷🇺Khanty-mansiysk, Russian Federation
Rostov Regional Clinical Hospital
🇷🇺Rostov on Don, Russian Federation
Samara Regional Clinical Hospital named after MI Kalinin
🇷🇺Samara, Russian Federation
Military Medical Academy HBAT
🇧🇬Pleven, Bulgaria
University Multiprofile Hospital for Active Treatment Aleksandrovska EAD
🇧🇬Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna ISUL EAD
🇧🇬Sofia, Bulgaria
Indywidualna Specjalistyczna Praktyka Lekarska Zbigniew Cebulski
🇵🇱Warminsko-mazurskie, Poland
Instytut Psychiatrii i Neurologii
🇵🇱Warszawa, Poland
Siberian Regional Medical Center
🇷🇺Novosibirsk, Russian Federation
Hope Neurology MS Center
🇺🇸Knoxville, Tennessee, United States
Tartu University Hospital
🇪🇪Tartu, Estonia
Latvian Maritime Medicine Centre
🇱🇻Riga, Latvia
Riga East Clinical University Hospital clinic Gailezers
🇱🇻Riga, Latvia
Akson Clinical Research Maciejowski Bielecki Sp. Jawna
🇵🇱Jaroslaw, Poland
Wojewodzki Szpital Specjalistyczny im Stefana Kardynala Wyszynskiego
🇵🇱Lublin, Poland
Niepubliczny Zaklad Opieki Zdrowotnej KENDRON
🇵🇱Podlaskie, Poland
Centrum Medyczne doktorA
🇵🇱Warszawa, Poland
Campus Neurologico Senior
🇵🇹Torres Vedras, Portugal
Cluj Clinical County Hospital
🇷🇴Cluj Napoca, Romania
Cai Ferate Clinical Hospital
🇷🇴Constanta, Romania
Kursk Regional Clinical Hospital
🇷🇺Kursk, Russian Federation
City Clinical Hospital 40
🇷🇺St. Petersburg, Russian Federation
Regional State Budget Institution of Healthcare Tver Regional Clinical Hospital
🇷🇺Tver, Russian Federation
National Research Center for Radiation Medicine, Institute of Clinical Radiology
🇺🇦Kyiv, Ukraine
Municipal Institution 6th City Clinical Hospital of Zaporizhzhia City Council
🇺🇦Zaporizhzhia, Ukraine
Research Center of Neurology of RAMS
🇷🇺Moscow, Russian Federation
Penza Regional Clinical Hospital na NN Burdenko
🇷🇺Penza, Russian Federation
Municipal Institution Dnipropetrovsk Regional Clinical Hospital na I.I. Mechnykov
🇺🇦Dnipropetrovsk, Ukraine
Ivano Frankivsk City Clinical Hospital 1
🇺🇦Ivano Frankivsk, Ukraine
City Hospital Nikolaevskaya Bolnitsa
🇷🇺St. Petersburg, Russian Federation
First St Petersburg State Medical University na IP Pavlov
🇷🇺St. Petersburg, Russian Federation
Clinical Center Nis
🇷🇸Nis, Serbia
MI Cherkasy Regional Hospital of Cherkasy Regional Council
🇺🇦Cherkasy, Ukraine
Municipal Institution Chernivtsi Regional Psychiatric Hospital
🇺🇦Chernivtsi, Ukraine
Kyiv City Clinical Hospital 4
🇺🇦Kyiv, Ukraine
Municipal Institution Odesa Regional Clinical Hospital
🇺🇦Odesa, Ukraine
Municipal Institution Vinnytsia Regional Psychoneurological Hospital na OI Yushchenko
🇺🇦Vinnytsia, Ukraine
Regional Clinical Hospital Center for Emergency Medical Care and Disaster Medicine
🇺🇦Kharkiv, Ukraine
Municipal Institution Zaporizhzhia
🇺🇦Zaporizhzhia, Ukraine
Lviv Regional Clinical Hospital
🇺🇦Lviv, Ukraine
Xenosciences Inc
🇺🇸Phoenix, Arizona, United States
St Josephs Hospital and Medical Center
🇺🇸Phoenix, Arizona, United States
Multiple Sclerosis Center at UCSF
🇺🇸San Francisco, California, United States
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
Szpital Czerniakowski Samodzielny Publiczny Zaklad Opieki Zdrowotnej
🇵🇱Warsaw, Poland
Denver Neurological Clinic
🇺🇸Denver, Colorado, United States
Providence Multiple Sclerosis Center
🇺🇸Portland, Oregon, United States
Karolinska Universitetssjukhuset Solna
🇸🇪Stockholm, Sweden
Axiom Clinical Research of Florida
🇺🇸Tampa, Florida, United States
Meridien Research
🇺🇸Tampa, Florida, United States
Center for Neurological Disorders
🇺🇸Milwaukee, Wisconsin, United States
Neurology Associates of Ormond Beach
🇺🇸Ormond Beach, Florida, United States
Praxis Dr. Wilfried Luer
🇩🇪Berlin, Germany
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States