Immunologic Biomarker Profile of Cerebrospinal Fluid
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Enrollment
- 165
- Locations
- 1
- Primary Endpoint
- Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients who have had neuromyelitis ptica with anti-AQP4 antibodies, or anti- Myelin Oligodendrocyte Glycoprotein antibodies, or double seronegative antibodies.
- •Neuromyelitis Optica patients have been prospectively included in the OFSEP collection
- •Multiple sclerosis patients, isolated myelitis or optic neuritis patients, and symptomatic controls whose samples will come from the "NEURO" collection of the Hospital Biological Collections Center,
- •Patients have given their free consent for use of their samples in research
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of glial fibrillar acidic protein in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of neurofilament in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of Matrix metalloproteinase-9 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of Soluble CD27 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin 10 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of chitinase-3-like protein 1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin-6 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin-8 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin 17A in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin 1B in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
Time Frame: Baseline
enzyme-linked immunosorbent assay
Secondary Outcomes
- Level of neurofilament in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin-6 in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin 1B in cerebrospinal fluid in each group(Baseline)
- Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in each group(Baseline)
- Level of glial fibrillar acidic protein in cerebrospinal fluid in each group(Baseline)
- Level of chitinase-3-like protein 1 in cerebrospinal fluid in each group(Baseline)
- Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in each group(Baseline)
- Level of Matrix metalloproteinase-9 in cerebrospinal fluid in each group(Baseline)
- Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in each group(Baseline)
- Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin-8 in cerebrospinal fluid in each group(Baseline)
- Level of Soluble CD27 in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin 10 in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin 17A in cerebrospinal fluid in each group(Baseline)