Immunologic Biomarker Profile of Cerebrospinal Fluid
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 165
- 试验地点
- 1
- 主要终点
- Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
研究概览
简要总结
The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who have had neuromyelitis ptica with anti-AQP4 antibodies, or anti- Myelin Oligodendrocyte Glycoprotein antibodies, or double seronegative antibodies.
- •Neuromyelitis Optica patients have been prospectively included in the OFSEP collection
- •Multiple sclerosis patients, isolated myelitis or optic neuritis patients, and symptomatic controls whose samples will come from the "NEURO" collection of the Hospital Biological Collections Center,
- •Patients have given their free consent for use of their samples in research
排除标准
- 未提供
结局指标
主要结局
Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of glial fibrillar acidic protein in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of neurofilament in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of Matrix metalloproteinase-9 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of Soluble CD27 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin 10 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of chitinase-3-like protein 1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin-6 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin-8 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin 17A in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
Level of Interleukin 1B in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein
时间窗: Baseline
enzyme-linked immunosorbent assay
次要结局
- Level of neurofilament in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin-6 in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin 1B in cerebrospinal fluid in each group(Baseline)
- Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in each group(Baseline)
- Level of glial fibrillar acidic protein in cerebrospinal fluid in each group(Baseline)
- Level of chitinase-3-like protein 1 in cerebrospinal fluid in each group(Baseline)
- Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in each group(Baseline)
- Level of Matrix metalloproteinase-9 in cerebrospinal fluid in each group(Baseline)
- Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in each group(Baseline)
- Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin-8 in cerebrospinal fluid in each group(Baseline)
- Level of Soluble CD27 in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin 10 in cerebrospinal fluid in each group(Baseline)
- Level of Interleukin 17A in cerebrospinal fluid in each group(Baseline)