Effects of GLP-1 Receptor Agonists on Bile Acid Metabolism and Intestinal Microorganisms: Identification of Association with Nonalcoholic Fatty Liver

Kyung Hee University Hosipital at Gangdong0 个研究点目标入组 22 人开始时间: 待定最近更新: 2020年4月21日

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•1) Adults between 20 and 75 years of age diagnosed with type 2 diabetes
•2) Patients with poor control of blood sugar level of 7.0% or more of HbA1c even though metformin and sulfone urea were used in combination for more than 2 months
•3) Those who voluntarily agreed to participate in the study

•a. If you have a liver disease of a specific cause, such as viral hepatitis, autoimmune hepatitis, alcoholic liver disease
•b. Drug users who can affect blood sugar, fatty liver, and gut microflora
•(Within 3 months from the study start date)
•-Glycocorticoid
•-Nonsteroidal anti-inflammatory
•-Immunosuppressive
•-All kinds of antibiotics
•-DPP4 inhibitors
•-alpha glucosidase inhibitors
•-Probiotics
•-Hepatotonics, including UDCA
•c. If the laboratory test results below are abnormal
•-estimated GFR <30 ml / min / 1.73 m2
•d. Drug abuser
•e. Pregnant and lactating women
•f. People on dialysis for terminal renal failure
•g. Beneficiaries of organ transplants, including the liver
•h. Those who have undergone surgery to modify the structure of the intestine (eg gastrointestinal resection)
•i. 30g men a day, 20g women or more drinkers
•j. Those who have received clinical trial drugs within the last 3 months
•k. In addition, those judged to be impossible to participate

发起方

Kyung Hee University Hosipital at Gangdong