Lung Cancer and Idiopathic Pulmonary Fibrosis : Pathological and Molecular Characterization
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Molecular profile of IPF-associated lung carcinomas
研究概览
简要总结
Retrospective inclusion of lung cancers developed in a context of idiopathic pulmonary fibrosis, diagnosed and / or treated in participating centers. The cases are recovered retrospectively from the records of the pulmonology and pathology departments of our various partners.
详细描述
Primary objective:
Characterize altered molecular pathways in lung cancer in patients with IPF versus lung cancer in non-IPF patients.
Secondary objectives:
Identify specific therapeutic targets Describe a cohort of lung cancers on IPF (clinical / radiological and pathological data) To study the relationship between neoplastic / preneoplastic lesions and pulmonary parenchyma reshaped by fibrosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Lung carcinoma
- •Idiopathic pulmonary fibrosis
排除标准
- •No tumor sample available
结局指标
主要结局
Molecular profile of IPF-associated lung carcinomas
时间窗: 1 month / 8 samples
Next generation sequencing of carcinomas with Ion S5 XL sequencer and Oncomine™ Comprehensive Panel
次要结局
- Pathological characterization of lung carcinomas(1 month / 8 samples)