Study of the prevalence of bronchial asthma among patients with periodontitis: a prospective observational study

The study employs a prospective observational design to investigate the relationship between periodontitis and bronchial asthma. This study aims to understand bronchial asthma’s prevalence and severity among periodontitis patients, shedding light on their complex relationship and influencing factors. The study population consists of 400 outpatients, aged 18-50 recruited from the Department of Periodontics and Implantology at KLE Society s Institute of Dental Sciences,  Banglore, diagnosed with periodontitis as per the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Participants meeting the inclusion criteria will undergo clinical assessments for periodontitis severity and will be classified into 2 groups, patients with history of asthma and without history of asthma according to the spirometry values and medical history. Periodontal parameters including plaque index, gingival index, probing pocket depth, and clinical attachment loss will be evaluated by a periodontist. Immunological (IL-6,TNF- alpha, NF- kappa B) and microbiological parameters(Porphyromonas gingivalis, Treponema denticola, Tanerella forsythia) will be assessed using Multiplex RT-PCR test kits. Lung function tests will categorize bronchial asthma severity. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC will be calculated for all participants. The FEV1 values greater  than 80%, 80-60%, and less than 60% are considered mild, moderate, and severe, respectively. Lung function test along with medical history will provide comprehensive data on respiratory health. At the beginning of the test, the participants’ demographic data will be recorded. The study duration is projected to last for 6 months..