Efficacy and Safety of Purified Starch for Adhesion Prevention in Colorectal Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Adhesions Abdominal
- Sponsor
- Taipei Medical University Shuang Ho Hospital
- Enrollment
- 83
- Locations
- 1
- Primary Endpoint
- Adhesion severity
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Intra-abdominal adhesion occurs in up to 90% of patients after abdominal surgery. Many patient will undergo a second surgery for temporary stoma closure, therefore these ostomy closure operations can give an opportunity to evaluate adhesion caused by previous operations. This study was conducted to use second surgery to investigate the anti-adhesion effect of purified starch among patients who underwent colorectal surgery.
Detailed Description
Data was analyzed from the medical records of patients who underwent a second surgery after colectomy between January 2020 and April 2022. Patient were allocated to either the purified starch group and control group. Since January 2020, adhesion scores have been registered in operation note when patients undergo a second colorectal surgery. The primary outcomes in this study were adhesion severity and adhesion area. The secondary outcomes were operation time, blood loss, and postopera-tive complications.
Investigators
Tungcheng Chang
Chief of department of colorectal surgery
Taipei Medical University Shuang Ho Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients who underwent a second surgery after colorectal resection between January 2020 and April 2022 were enrolled into this study.
Exclusion Criteria
- •Patients who underwent a second surgery less than 1 month after the first colorectal resection or who developed peritoneum carcinomatosis in the second surgery and patients younger than 20 years were excluded.
Outcomes
Primary Outcomes
Adhesion severity
Time Frame: three to six months
Adhesion severity was scored as grade 0 (no adhesion), grade I (filmy adhesion and blunt dissection), grade II (strong adhesion and sharp dissection), and grade III (very strong vascularized adhesion, sharp dissection, and damage barely preventable).
Adhesion area
Time Frame: three to six months
Adhesion area was scored as grade 0 (no adhesion), grade I (adhesion of less than one-third of the area between the abdominal wall and the visceral organ in the lower abdominal cavity), grade II (adhesion of one-third and two-thirds of the area between the abdominal wall and the visceral organ in the lower abdominal cavity), and grade III (adhesion of more than two-thirds of the area between the abdominal wall and the visceral organ in the lower abdominal cavity).