Combination of Psychosocial Intervention and Slow Prosecutions for the Treatment of Methamphetamine Abuse/Dependence

Not Applicable

• Conditions: Amphetamine Abuse; Amphetamine Dependence; Methamphetamine Abuse; Methamphetamine Dependence
• Interventions: Behavioral: Psychosocial intervention; Behavioral: Telephone reminding

• Registration Number: NCT01273701
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The hospital where this study will be conducted is responsible for the one-year contingency management treatment for methamphetamine drug offenders referred from the Yunlin District Prosecutors Office. Completing the one-year treatment is prerequisite for offenders to get slow prosecutions.

It is an open-label, parallel-group trial comparing the combination of psychosocial intervention and slow prosecutions with psychosocial intervention alone in treating subjects with methamphetamine dependence

Study Hypothesis

1. Psychosocial interventions in combination with slow prosecutions is more effective than psychosocial interventions alone to achieve abstinence for subjects with methamphetamine abuse/dependance.

2. Inclusion of telephone reminding before each visit will enhance the retention rate and abstinence rate.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-12
• Study Start: 2011-01
• Study First Submitted: 2011-01-06
• Study First Submitted QC: 2011-01-06
• Last Update Submitted: 2011-01-06
• Study First Posted: 2011-01-10
• Last Update Posted: 2011-01-10
• Primary Completion: 2012-12
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• DSM-IV-TR criteria for amphetamine/methamphetamine abuse or dependence
• 18 - 65 years old
• For TSTSU-N and TSTSU-T arms: methamphetamine offenders referred by the Yunlin District Prosecutors Office
• For OPD arm: psychiatric outpatients referred from the psychiatry clinics in National Taiwan University Hospital, Yunlin Branch

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Exclusion Criteria

• Concurrent use of other illicit substances
• Co-morbidity with major psychotic disorders (schizophrenia, schizoaffective disorder, other psychotic disorder), mental retardation, acute episodes of major depressive disorder or bipolar affective disorder) or serious personality disorders.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TSTSU-N	Psychosocial intervention	TSTSU-N stands for Treatment for Schedule Two Substance Use, No Telephone Reminding. Subjects will be referred by the Yunlin District Prosecutors Office for one-year psychosocial interventions to get slow prosecutions. After the referral, they will be randomized in a 1:1 ratio to either TSTSU-N group or TSTSU-T group. During the intervention, subjects of TSTSU-N will not receive telephone reminding before each visit.
TSTSU-T	Psychosocial intervention	TSTSU-T stands for Treatment for Schedule Two Substance Use, Telephone Reminding. Subjects will be referred by the Yunlin District Prosecutors Office for one-year psychosocial interventions to get slow prosecutions. After the referral, they will be randomized in a 1:1 ratio to either TSTSU-N group or TSTSU-T group. During the intervention, subjects of TSTSU-T will receive telephone reminding before each visit.
TSTSU-T	Telephone reminding	TSTSU-T stands for Treatment for Schedule Two Substance Use, Telephone Reminding. Subjects will be referred by the Yunlin District Prosecutors Office for one-year psychosocial interventions to get slow prosecutions. After the referral, they will be randomized in a 1:1 ratio to either TSTSU-N group or TSTSU-T group. During the intervention, subjects of TSTSU-T will receive telephone reminding before each visit.
OPD	Psychosocial intervention	OPD stands for Outpatient Department. Subjects in this arm will be methamphetamine users who voluntarily visit psychiatric clinics for treatment of mental disorders in National Taiwan University Hospital, Yunlin Branch. They will be referred to this study by their treating psychiatrists.

Primary Outcome Measures

Name	Time	Method
Endpoint abstinence rate	At the end of one-year treatment	According to the urine amphetamine/methamphetamine screen after the one-year treatment, negative result suggests successful abstinence.

Secondary Outcome Measures

Name	Time	Method
Retention rate	during the whole one-year treatment	proportion of subjects who can complete the course of one-year treatment
Length of retention	during the whole one-year treatment	the averaged duration of attending treatment
The longest period of abstinence	during the whole one-year treatment	the longest period of time with successive negative results of urine amphetamine/methamphetamine tests or negative reports of recent methamphetamine use

Trial Locations

Locations (1)

National Taiwan University Hospital Yunlin Branch; 🇨🇳 Yunlin, Taiwan