Combination of Psychosocial Intervention and Slow Prosecutions for the Treatment of Methamphetamine Abuse/Dependence

Not Applicable

• Conditions: Amphetamine Abuse; Amphetamine Dependence; Methamphetamine Abuse; Methamphetamine Dependence

• Registration Number: NCT01273701
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The hospital where this study will be conducted is responsible for the one-year contingency management treatment for methamphetamine drug offenders referred from the Yunlin District Prosecutors Office. Completing the one-year treatment is prerequisite for offenders to get slow prosecutions.

It is an open-label, parallel-group trial comparing the combination of psychosocial intervention and slow prosecutions with psychosocial intervention alone in treating subjects with methamphetamine dependence

Study Hypothesis

1. Psychosocial interventions in combination with slow prosecutions is more effective than psychosocial interventions alone to achieve abstinence for subjects with methamphetamine abuse/dependance.

2. Inclusion of telephone reminding before each visit will enhance the retention rate and abstinence rate.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-12
• Study Start: 2011-01
• Study First Submitted: 2011-01-06
• Study First Submitted QC: 2011-01-06
• Last Update Submitted: 2011-01-06
• Study First Posted: 2011-01-10
• Last Update Posted: 2011-01-10
• Primary Completion: 2012-12
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• DSM-IV-TR criteria for amphetamine/methamphetamine abuse or dependence
• 18 - 65 years old
• For TSTSU-N and TSTSU-T arms: methamphetamine offenders referred by the Yunlin District Prosecutors Office
• For OPD arm: psychiatric outpatients referred from the psychiatry clinics in National Taiwan University Hospital, Yunlin Branch

Exclusion Criteria

• Concurrent use of other illicit substances
• Co-morbidity with major psychotic disorders (schizophrenia, schizoaffective disorder, other psychotic disorder), mental retardation, acute episodes of major depressive disorder or bipolar affective disorder) or serious personality disorders.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Endpoint abstinence rate	At the end of one-year treatment	According to the urine amphetamine/methamphetamine screen after the one-year treatment, negative result suggests successful abstinence.

Secondary Outcome Measures

Name	Time	Method
Retention rate	during the whole one-year treatment	proportion of subjects who can complete the course of one-year treatment
Length of retention	during the whole one-year treatment	the averaged duration of attending treatment
The longest period of abstinence	during the whole one-year treatment	the longest period of time with successive negative results of urine amphetamine/methamphetamine tests or negative reports of recent methamphetamine use

Trial Locations

Locations (1)

National Taiwan University Hospital Yunlin Branch; 🇨🇳 Yunlin, Taiwan

National Taiwan University Hospital Yunlin Branch

🇨🇳Yunlin, Taiwan

Yi-Ting Lin, M.D.

Principal Investigator

Li-Ren Chang, M.D.

Sub Investigator