Effect of calcium chloride on recovery from neuromuscular block
Not Applicable
- Conditions
- Surgery
- Registration Number
- PACTR201811703495809
- Lead Sponsor
- Mansoura University Hospitals.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
adult patients of either sex.
18 to 65 years old.
ASA physical status I–III. scheduled for elective surgery under general anesthesia with intubation of the trachea, of an expected duration of = 60 min
Exclusion Criteria
Patients with the suspected difficult airway.
Chronic obstructive pulmonary disease or bronchial asthma.
BMI = 40.
Neuromuscular diseases.
Suspected malignant hyperthermia.
Glaucoma.
renal or hepatic dysfunction.
Taking medications that could affect NMB agents action.
Pregnant or lactating women. Patients with hypo or hypercalcemia.
Hypo-albuminemia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The Extubation time
- Secondary Outcome Measures
Name Time Method 1.Recovery time (time from administration of neostigmine till reaching TOF ratio = 0.9).<br>2.Core body temperature, sevoflurane concentration, serum ionized calcium level, and arterial blood PH at the time of neostigmine administration.<br>3. Total atracurium dose used during the surgery. <br>4.TOFr at 5,10,20,30 min after neostigmine administration and at PACU arrival.<br>5.Time from neostigmine administration to PACU arrival.<br>6.The incidence of a residual neuromuscular block (TOFr less than 0.9 on quantitative monitoring) 13, measured at the same intervals as TOFr.<br>7.PACU discharge time (time from PACU admission till reaching modified Aldrete's score of = 9).<br>