Efficacy and Safety of the VABu Conditioning Regimen in Elderly Patients With Acute Myeloid Leukemia Undergoing Hematopoietic Stem Cell Transplantation: An Open-Label, Multicenter, Single-Arm Clinical Study
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 1
研究概览
简要总结
This is an open-label, multi-center, single-arm clinical study evaluating the efficacy and safety of the VABu conditioning regimen in elderly patients (≥60 years) with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (HSCT).
The VABu regimen consists of Venetoclax, Azacitidine, Semustine, Cytarabine, and Busulfan. All enrolled participants will receive the VABu regimen as conditioning therapy prior to HSCT.
The study aims to enroll 20 participants from multiple centers in China. The primary objectives are to evaluate the overall response rate, cumulative relapse rate, overall survival, graft-versus-host disease (GVHD)-free relapse-free survival (GRFS), non-relapse mortality (NRM), incidence of acute and chronic GVHD, and reactivation rates of cytomegalovirus (CMV) and Epstein-Barr virus (EBV). Safety outcomes include treatment-related toxicities, such as bone marrow suppression, infection, and organ dysfunction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 60 years.
- •Confirmed diagnosis of acute myeloid leukemia (AML) according to WHO classification, with intermediate or high-risk prognosis.
- •Previous response to Venetoclax-based therapy.
- •Planned to undergo allogeneic hematopoietic stem cell transplantation (HSCT).
- •Donor availability: Related donor matched at least 5/10 at HLA-A, -B, -C, -DQB1, and -DRB1; OR unrelated donor matched at least 8/10 at the same loci.
- •Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) score ≤
- •ECOG performance status 0-
- •Adequate organ function as defined by: Creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 45 mL/min (Cockcroft-Gault formula or 24-hour urine collection)； AST ≤ 3.0 × ULN and ALT ≤ 3.0 × ULN； Total bilirubin ≤ 1.5 × ULN； Left ventricular ejection fraction (LVEF) > 50%； Baseline oxygen saturation > 92%； DLCO ≥ 40% and FEV1 ≥ 50%；
- •Ability to understand and provide written informed consent.
排除标准
- •Age < 60 years.
- •Poor response to prior Venetoclax-based therapy.
- •Unstable systemic disease (unstable angina, myocardial infarction, cerebrovascular accident within 3 months; NYHA Class III-IV heart failure; severe arrhythmia; pulmonary hypertension).
- •Active uncontrolled infection or active bleeding in vital organs.
- •CNS symptoms grade ≥ 2 requiring treatment.
- •Major organ surgery within 6 weeks.
- •History of malignant disease other than AML within 5 years.
- •History of thrombosis, embolism, or cerebral hemorrhage within 1 year.
- •ECOG performance status >
- •HCT-CI score >
- •Organ failure meeting specified criteria.
- •Known HIV, active HBV, or active HCV infection.
- •History of autoimmune disease requiring systemic immunosuppressive therapy.
- •Pregnancy, breastfeeding, or unwillingness to use effective contraception in patients of childbearing potential.
- •Drug abuse or chronic alcoholism.
- •Psychiatric disorder or other condition compromising informed consent or compliance.
- •Any other condition making the patient unsuitable for study participation in the investigator's judgment.
研究组 & 干预措施
VaBU
干预措施: VaBU (Drug)
研究者
Huiying Qiu
Chief Physician；Professor
The First Affiliated Hospital of Soochow University