Serum Magnesium and Vascular Calcification
- Conditions
- Vascular CalcificationChronic Kidney Disease
- Registration Number
- NCT01293786
- Lead Sponsor
- Ramathibodi Hospital
- Brief Summary
Both Kidney transplantation (KT) and Chronic Kidney Disease (CKD) patients have reduced kidney function. Low serum magnesium is more prevalent in KT recipients. The present study examines the difference in vascular calcification between KT and CKD and its association with serum magnesium.
- Detailed Description
Kidney transplantation (KT) improved quality of life and longevity of CKD patients. Nevertheless, kidney function deteriorates overtime in a manner not different from CKD counterparts. Hypomagnesemia is prevalent in KT recipients secondary to immunosuppressive therapy. In addition to serum calcium, phosphate and elemental calcium intake, the relationship between low serum magnesium and vascular calcification (VC) has been observed in small studies in CKD. Whether low serum magnesium associates with VC in KT has never been elucidated. The present study compares vascular calcification between KT and CKD and its association with serum magnesium.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 400
- kidney transplant recipients at least 1 year post surgery
- predialysis chronic kidney disease with serum creatinine > 1.1 mg/dL in female and 1.3 mg/dL in male
- acute kidney injury
- parathyroidectomy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The difference in vascular calcification score between KT and CKD Baseline
- Secondary Outcome Measures
Name Time Method The association of serum magnesium with vascular calcification in CKD Baseline The association of serum magnesium with vascular calcification in KT Baseline
Trial Locations
- Locations (1)
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
🇹ðŸ‡Phayathai, Bangkok, Thailand