Randomized controlled clinical trial to evaluate the efficacy of Nagaradi Churna in the management of Tamakashwasa Avegavashta (Bronchial Ashtma)
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Kasa (Cough), Peenasa( Coryza),
研究概览
简要总结
There are 5 types of vata doshas out of which prana and udana vayu contribute to the process of respiration through pranavaha strotasa . The normal function of respiration through pranavaha strotasa, The normal fuunction of respiration is a sign of healthy life. The defect in pranavayu and udanavayu causes so many respiratory diseases out of which one is Tamakashwasa. The term Tamakashwasa is composed of two words 1)Tamak is derived from Tamas which means Andhakar that is darkness , 2) Shwasa is derived from Shwas which means Jivane which means living or life.
Vayu moving in pratiloma that is reverse order pervades the channel (of pranavaha) afflicts the head and the neck and stimulates phlegm to cause Peenasa (Coryza) . This obstructed vayus produces signs and symptoms like ghurghurkam dhwani (wheezing and murmur sounds) and dyspnea of exceedingly deep velocity which is immensely injurious to life. Patient get relief from symptoms soon after sputum expelled, develops special liking for hot things, eyeballs becomes projected outside.
Rationale- 1) The sedentery lifestyle environmental changes are the aggrevating factors in the bronchial asthma
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Global ,regional and national prevalence of bronchial asthma has been found around 8.8%
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In modern medicines bronchodilators , corticosteroids and inhalers are used in treatment which are having measure side effects. So with ayurvedic dinacharya , rutucharya , pathya apathya kalpana can treat the disease and reduce prevalencde and complications of asthma.
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The ingredients used in Nagaradi churna are easily available and are cost effective with very minimal or no adverse drug effect.
Hypothesis-
A) Null Hypothesis- Nagaradi Churna is not effective in the management of Tamakashwasa-Avegavastha (Bronchial Asthma)
B) Alternative Hypothesis- Nagaradi Churna is effective in the management of Tamakshwasa-Avegavastha (Bronchial Asthma)
The study will be conducted on 92 patients with 46 patients of trial group will be treated with Nagaradi Churna and the other 46 patients of Control group will be treated with Talisadi Churna and the result will be conducted.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients having sign and symptoms of Tamakashwasa mentioned in ayurvedic samhitas will be selected such as Shwasakrichhrata (Breathlessness), Kasa (Cough), Ghurghurkam Dhwani (wheezing), Kaphasthivana Krichhrata (Difficulty in expectoration), Peenasa(Coryza).
排除标准
- •Patients of ARDS, COPD, TB, CA lung.
- •Patients having comorbidity like HTN, DM, AIDS or other systemic and endocrine diseases.
- •Patients having psychological and neurological disorders.
- •Steroid dependent patients more than 1year.
- •Pregnant and lactating women.
- •Patient age less than 20 years and more than 40 years.
结局指标
主要结局
Kasa (Cough), Peenasa( Coryza),
时间窗: 21 days
Ghurghurkam Dhwani (Wheezing) this lakshanas will be decreased.
时间窗: 21 days
次要结局
- Shwasakricchrata (Breathlessness) , Kaphashtivana kricchrata (Difficulty in expectoration) this lakshanas will be decreased.(21days)
研究者
Dr Sanobar Shakil Mulani
C.S.M.S.S. ayurved mahavidyalaya and rugnalaya kanchanwadi Aurangabad Maharashtra India 431011