Dynamic Changes of Gut Microbiota in Patients With Ulcerative Colitis After Fecal Transplantation
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- changes of gut microbiota
研究概览
简要总结
A prospective study to investigate the dynamic changes of gut microbiota through colonic transendoscopic enteral tubing in patients with ulcerative colitis after fecal microbiota transplantation.
详细描述
Colonic transendoscopic enteral tubing (TET) is a novel, safe, convenient, and reliable way for fecal microbiota transplantation (FMT) and the whole-colon enema treatment. This tube also can serve as a medium for collecting gut microbiota. Fecal Microbiota Transplantation (FMT) was identified to be promising for ulcerative colitis (UC). This study aims to investigate the dynamic changes of gut microbiota in patients with UC after FMT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients were diagnosed with mild or moderate ulcerative colitis.
- •Patients need colonic TET and FMT
- •Must be able to colonic TET and no contraindication by endoscopic examination, consent colon TET implantation and not associated with severe intestinal lesions such as fistula, stenosis, complex perianal lesions, severe ileocecal or ascending colon lesions resulting in no proper site for titanium clip fixation.
- •Age > 7 years old and < 65 years old
排除标准
- •gut microbiota was not collected successfully
研究组 & 干预措施
colonic TET and FMT
gut microbiota will be collected through the colonic TET after FMT
干预措施: colonic transendoscopic enteral tubing (Device)
结局指标
主要结局
changes of gut microbiota
时间窗: 7 days
gut microbiota will be collected through the colonic TET
次要结局
- frequency of defecation(7 days)