99Tc-MDP Treatment for Knee Osteoarthritis
- Registration Number
- NCT02993029
- Brief Summary
Osteoarthritis (OA) of knee is the most common form of arthritis in the world1e, and it has received growing attention in the society because of the increase of old age population, disabled people, and medical expenses from this disease. 99Tc-MDP is effective for rheumatoid arthritis. Therefore, the investigators try to investigate the effects of 99Tc-MDP treatment in patients with osteoarthritis of knee as compared with celecoxib.
- Detailed Description
The prevalence of osteoarthritis of the knee (OA) is increasing worldwide and this burden will continue to increase owing to aging of the general population 99Tc-MDP is effective for rheumatoid arthritis. Consequent to an increase in incidence is the rise in the number of patients with knee OA who are prone to further deterioration of the knee. It therefore is important to better understand, control, and attempt to prevent further progression of disease in patients with knee OA. Limitations in walking, stair climbing, and squatting are common patient complaints that greatly interfere with activities of daily living and recreation. Currently there is no definite consensus on the standardized management of OA. Oral analgesic and anti-inflammatory agents are perhaps the most commonly prescribed treatments to alleviate knee OA symptoms. The failure of nonsurgical therapies to modify quality of life in knee OA patients is not surprising given their inability to alleviate physical manifestations of OA. Surgical knee OA interventions generally result in good to excellent patient outcomes. However, there are significant barriers to considering surgery, which limits clinical utility.
99Tc-MDP is actually the decay product of 99mTc-MDP (99mTc-methylene diphosphonate, a US Food and Drug Administration-approved radioactive agent widely used for bone scintigraphy). 99Tc-MDP (Chengdu Yunke Pharmaceutical, Sichuan, China) is a kind of anti-inflammatory drug patented in China (patent no. ZL94113006.1). It was approved for production by the State Food and Drug Administration of China in October 1997. 99Tc-MDP has been demonstrated to be safe and effective in the clinical treatment of immune diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis (AS) and certain bone diseases, such as skeletal metastases from cancer in China. 99Tc-MDP also showed clinical effect on knee OA in our practice. Therefore, the investigators try to investigate the effects of 99Tc-MDP treatment in patients with osteoarthritis of knee as compared with celecoxib.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 40
- Participants with painful osteoarthritis;
- The standard uptake value (SUV) of OA related knee greater than 10 on 18F- sodium fluoride bone scan;
- Participants voluntarily participate in the trial, and signed the informed consent.
- Knee joint replacement;
- Inflammatory arthritis or joint infection of knee;
- Nervous joint disease;
- Fracture of joint;
- Gout arthritis of the knee;
- Traumatic arthritis.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 99Tc-MDP 99Tc-MDP 99Tc-MDP group:15mg in 100ml normal saline intravenously dripped every twice a week for 5 weeks, every 1weeks for 10 weeks, every 2weeks for 10 weeks, every 1 month for 6 months. celecoxib Celecoxib celecoxib capsule 200mg qd by mouth.
- Primary Outcome Measures
Name Time Method pain, stiffness and joint function of knee baseline, and 6, 12 months after treatment. change of the pain, stiffness and joint function of knee (mean and standard deviation) by Western Ontario and McMaster Universities (WOMAC)Osteoarthritis Index
- Secondary Outcome Measures
Name Time Method standard uptake value of knee baseline and 12 months after treatment. change of standard uptake value (SUV,mean and standard deviation) of knee on 18F- sodium fluoride or 99Tc-MDP bone scan and change of cystic area on according CT
adverse events 3, 6, 12 months after treatment. adverse events that are related to treatment
health-related quality of life baseline, and 6, 12 months after treatment. change of health-related quality of life (mean and standard deviation) by SF-36
staging of knee osteoarthritisby baseline and 12 months after treatment. number of participants who have change of knee osteoarthritis staging by X-ray or CT
Trial Locations
- Locations (1)
Department of Nuclear Medicine, Tenth People's Hospital of Tongji University
🇨🇳Shanghai, Shanghai, China