Preoperative Pain Control in Liver Surgery Patients
Not Applicable
Completed
- Conditions
- Pain, PostoperativeHepatocellular Carcinoma
- Interventions
- Drug: Placebo (for Pregabalin)
- Registration Number
- NCT01923948
- Lead Sponsor
- Eastern Hepatobiliary Surgery Hospital
- Brief Summary
Pregabalin 150mg or placebo are administered 1 hour preoperatively in patients undergoing partial hepatectomy. Postoperatively, patients receive morphine as rescue analgesic. Morphine consumption in the first 48 hours is documented. Postoperative pain is measured by the visual analogue scale (VAS) score.
- Detailed Description
Methods: In this Randomized Controlled Trial, patients undergoing partial hepatectomy will be administered a single pre-operative dose of Pregabalin or a placebo. Primary endpoints are as follows:
* Post-operative analgesic requirements
* Post-operative VAS scale (rated 0-10)
* Complications
* Post-operative antiemetic requirement
* Length of stay
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- patients undergoing partial hepatectomy
Exclusion Criteria
- contraindication against pregabalin
- creatinine > 2.0 mg/dl
- GGT >165, AST >105, ALT >135
- peptic Ulcus
- haemorrhagic diathesis
- angina pectoris, myocardial infarction
- stroke
- bronchial asthma
- opioid abuse
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sugar Pill Placebo (for Pregabalin) Single, placebo pre-operative dose Pregabalin Pregabalin Single, 150 mg pre-operative oral dose of Pregabalin
- Primary Outcome Measures
Name Time Method Postoperative Opioid Consumption 48 hours
- Secondary Outcome Measures
Name Time Method Postoperative Pain Scores on the Visual Analog Scale 24 hours
Trial Locations
- Locations (1)
Eastern Hepatobiliary Surgery Hospital
🇨🇳Shanghai, China